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Anti-p19 INK4d Antibody (1B259)
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Catalog No. TMAY-02381
Alias p19-INK4D, p19, INK4D, cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
Anti-p19 INK4d Antibody (1B259) is a Mouse antibody targeting p19 INK4d. Anti-p19 INK4d Antibody (1B259) can be used in ELISA.
Anti-p19 INK4d Antibody (1B259)
Anti-p19 INK4d Antibody (1B259)
😃Good
Catalog No. TMAY-02381Alias p19-INK4D, p19, INK4D, cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
Anti-p19 INK4d Antibody (1B259) is a Mouse antibody targeting p19 INK4d. Anti-p19 INK4d Antibody (1B259) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $199 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-p19 INK4d Antibody (1B259) is a Mouse antibody targeting p19 INK4d. Anti-p19 INK4d Antibody (1B259) can be used in ELISA. |
| Alias | p19-INK4D, p19, INK4D, cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 1B259 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CDKN2D / p19ink4d (rh CDKN2D / p19ink4d; TMPY-02495; P55273; Met 10-Leu 166). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Cyclin-dependent kinase inhibitor 2D(also known as CDKN2D or p19ink4d), a member of the INK4 family of cyclin-dependent kinase (CDK) inhibitors, negatively regulates the cyclin D-CDK4/6 complexes, which promote G1/S transition by phosphorylating the retinoblastoma tumor-suppressor gene product. It is clearly shown that DNA repair is the main target of p19ink4d effect and that diminished apoptosis is a downstream event. Experiments has uncovered a role of p19INK4d as a regulator of DNA-damage-induced apoptosis and suggest that it protects cells from undergoing apoptosis by allowing a more efficient DNA repair. It has been demonstrated that p19INK4d expression enhances cell survival under genotoxic conditions. Previous work has shown that inactivation of the cyclin-dependent kinase inhibitor (CKI) p19(Ink4d) leads to progressive hearing loss attributable to inappropriate DNA replication and subsequent apoptosis of hair cells. It may also involved in male reproductive function including testicular atrophy, alteration in serum follicle stimulating hormone, qualitative increase in germ cell apoptosis, and delayed kinetics of meiotic prophase markers. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human CDKN2D / p19ink4d protein (TMPY-02495) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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