Contact UsQuotation
Shopping Cart
Remove All
  • TargetMol
    Your shopping cart is currently empty
Proceed to checkoutContinue shopping
TOPBioactivityChemical infoStorage&SolubilityCalculator

3-Amino-1,2,4-triazole

Copy Product Info
😃Good
Catalog No. T67498Cas No. 61-82-5
Alias Trapidil impurity B, Amitrole, 3-AT, 1H-1,2,4-Triazol-5-amine

3-Amino-1,2,4-triazole (Trapidil impurity B) is an inhibitor of catalase, capable of inducing the compensatory mechanism for hydrogen peroxide detoxification. This mechanism involves increasing the activities of glutathione peroxidase and glutathione reductase.

3-Amino-1,2,4-triazole

3-Amino-1,2,4-triazole

Copy Product Info
😃Good
Purity: 98.74%
Catalog No. T67498Alias Trapidil impurity B, Amitrole, 3-AT, 1H-1,2,4-Triazol-5-amineCas No. 61-82-5
3-Amino-1,2,4-triazole (Trapidil impurity B) is an inhibitor of catalase, capable of inducing the compensatory mechanism for hydrogen peroxide detoxification. This mechanism involves increasing the activities of glutathione peroxidase and glutathione reductase.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 g$41-In Stock
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
TargetMol
View More

Batch Information

Select Batch
Purity:98.74%
Appearance:Solid
Color:White
Contact us for more batch information

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity
Description
3-Amino-1,2,4-triazole (Trapidil impurity B) is an inhibitor of catalase, capable of inducing the compensatory mechanism for hydrogen peroxide detoxification. This mechanism involves increasing the activities of glutathione peroxidase and glutathione reductase.
In vitro
3-Amino-1,2,4-triazole (1,10 and 100 microg/ml ) had no significant cytotoxicity to the FRTL-5 cells (P > 0.05). The concentration of thyroglobulin (TG) in the culture was decreased by 10 and 100 microg/ml 3-Amino-1,2,4-triazole (P < 0.05), and the concentration of TG in the cells was decreased by 100 microg/ml (P < 0.05) but the TTF-1 in the cells were not obviously changed (P > 0.05). The TSHR in the surface of FRTL-5 cells was significantly decreased by all doses of 3-Amino-1,2,4-triazole (P < 0.01). The influence of 3-Amino-1,2,4-triazole on TG of FRTL-5 cells may be related to significantly reduce TSHR in the surface of FRTL-5 cells.[1]
SynonymsTrapidil impurity B, Amitrole, 3-AT, 1H-1,2,4-Triazol-5-amine
Chemical Properties
Molecular Weight84.08
FormulaC2H4N4
Cas No.61-82-5
SmilesNC1=NN=CN1
Relative Density.1.138 g/cm3
Storage & Solubility Information
StorageIn solvent: -80°C for 1 year
Solubility Information
DMSO: 90 mg/mL (1070.41 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM11.8934 mL59.4672 mL118.9343 mL594.6717 mL
5 mM2.3787 mL11.8934 mL23.7869 mL118.9343 mL
10 mM1.1893 mL5.9467 mL11.8934 mL59.4672 mL
20 mM0.5947 mL2.9734 mL5.9467 mL29.7336 mL
50 mM0.2379 mL1.1893 mL2.3787 mL11.8934 mL
100 mM0.1189 mL0.5947 mL1.1893 mL5.9467 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

ReactiveOxygenSpeciesReactive Oxygen SpeciesCatalase3-Amino-1,2,4-triazole
Related Tags: buy 3-Amino-1,2,4-triazole | purchase 3-Amino-1,2,4-triazole | 3-Amino-1,2,4-triazole cost | order 3-Amino-1,2,4-triazole | 3-Amino-1,2,4-triazole chemical structure | 3-Amino-1,2,4-triazole in vitro | 3-Amino-1,2,4-triazole formula | 3-Amino-1,2,4-triazole molecular weight
TargetMol | Logo

Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.