store at low temperture,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Disitertide acetate (P144 acetate) is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor. Disitertide acetate is also a PI3K inhibitor and an apoptosis inducer.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 152.00 | |
2 mg | In stock | $ 228.00 | |
5 mg | In stock | $ 326.00 | |
10 mg | In stock | $ 527.00 | |
25 mg | In stock | $ 853.00 | |
50 mg | In stock | $ 1,180.00 | |
100 mg | In stock | $ 1,590.00 |
Description | Disitertide acetate (P144 acetate) is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor. Disitertide acetate is also a PI3K inhibitor and an apoptosis inducer. |
In vitro | Disitertide acetate (P144, 100 μg/mL) suppresses the protein expression levels of PI3K and p-Akt, and induce the protein expression of Bax in MC3T3-E1 cells[2]. Disitertide acetate (TGF-β1 inhibitor) abrogates the MACC1- AS1 expression in GC cells, suggesting that targeting TGFβ signaling pathway may be a potential strategy to inhibit MSC-induced stemness and chemoresistance[3]. Disitertide acetate (10 μg/mL to 200 μg/mL) affects proliferation, induces apoptosis as well as anoikis in A172 and U-87 MG GBM cell lines[5]. |
In vivo | Disitertide acetate (Topical application, 300 μg/mL) may promote scar maturation and improvement of hypertrophic scar morphology features in an “in vivo” model in nude mice after two weeks of treatment[4]. |
Synonyms | P144 acetate, Disitertide acetate(272105-42-7 Free base) |
Molecular Weight | 1640.88 |
Formula | C70H113N17O24S2 |
store at low temperture,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Disitertide acetate Stem Cells TGF-beta/Smad P 144 Acetate Disitertide Acetate P144 acetate Disitertide acetate(272105-42-7 Free base) P-144 Acetate P144 Acetate inhibitor inhibit