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AC-73

Name: AC-73
Brand: TargetMol
SKU: T14091
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14091Cas No. 775294-71-8

AC-73 is an orally available Cluster of Differentiation 147 (CD147) inhibitor with high bioavailability that selectively disrupts the dimerization of CD147 (the binding site is in the N-terminal IgC2 domain of CD147 including Glu64 and Glu73), resulting in inhibition of the CD147/ERK1/2/STAT3/MMP-2 pathway and inhibition of liver cancer cell motility and invasion. AC-73 has antiproliferative activity and induces autophagy in leukemia cells.

AC-73

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Purity: 99.36%

Catalog No. T14091Cas No. 775294-71-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$45	In Stock	In Stock
5 mg	$98	In Stock	In Stock
10 mg	$183	In Stock	In Stock
25 mg	$322	In Stock	In Stock
50 mg	$540	In Stock	In Stock
100 mg	$957	In Stock	In Stock
500 mg	$1,920	-	In Stock
1 mL x 10 mM (in DMSO)	$110	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.36%

Appearance:Solid

Color:Red

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	AC-73 is an orally available Cluster of Differentiation 147 (CD147) inhibitor with high bioavailability that selectively disrupts the dimerization of CD147 (the binding site is in the N-terminal IgC2 domain of CD147 including Glu64 and Glu73), resulting in inhibition of the CD147/ERK1/2/STAT3/MMP-2 pathway and inhibition of liver cancer cell motility and invasion. AC-73 has antiproliferative activity and induces autophagy in leukemia cells.
In vitro	AC-73 (5-10 μM; 24 hours; SMMC-7721 and Huh-7 cells) treatment results in a dose-dependent reduction in the migration and invasion of these HCC cell lines, with no significant effect on cell viability at 20 μM. AC-73 potentially binds to CD147 at Glu64 and Glu73 in the N-terminal IgC2 domain, which are located within the CD147 dimer interface. AC-73 (5-10 μM; 24 hours; SMMC-7721 cells), at 10 μM, significantly inhibits the mRNA expression of MMP-2 and MMP-9, especially MMP-2, without affecting MMP-1, MMP-3, MMP-7, MMP-11, or MMP-13, and reduces MMP-2 mRNA levels and protein secretion as confirmed by RT-qPCR and gelatin zymography. AC-73 (5-20 μM; 6 hours; SMMC-7721 cells) also dose-dependently attenuates ERK1/2 and STAT3 phosphorylation.
In vivo	AC-73 (25-50 mg/kg; Injected; daily; for 3 weeks; Male BALB/c nu/nu mice with SMMC-7721 cells) treatment significantly decreases the incidence of metastatic foci in nude mice, inhibits the phosphorylation of ERK1/2 and STAT3 in a dose-dependent manner, and reduces MMP-2, but does not inhibit tumor cell proliferation in vivo.[1]

Chemical Properties

Molecular Weight	319.4
Formula	C₂₁H₂₁NO₂
Cas No.	775294-71-8
Smiles	OC(CNCc1ccc(cc1)-c1ccccc1)c1cccc(O)c1
Relative Density.	1.181 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 245 mg/mL (767.06 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (12.52 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1309 mL	15.6544 mL	31.3087 mL	156.5435 mL
5 mM	0.6262 mL	3.1309 mL	6.2617 mL	31.3087 mL
10 mM	0.3131 mL	1.5654 mL	3.1309 mL	15.6544 mL
20 mM	0.1565 mL	0.7827 mL	1.5654 mL	7.8272 mL
50 mM	0.0626 mL	0.3131 mL	0.6262 mL	3.1309 mL
100 mM	0.0313 mL	0.1565 mL	0.3131 mL	1.5654 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc