Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NRX-252114 (NRX252114) induces degradation of mutant β-catenin NRX-252114 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP, and is able to enhance the binding of pSer33/S37A β-catenin to β-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. Kd is 0.4 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 196.00 | |
5 mg | In stock | $ 497.00 | |
10 mg | In stock | $ 723.00 | |
25 mg | In stock | $ 1,130.00 | |
50 mg | In stock | $ 1,520.00 | |
100 mg | In stock | $ 1,980.00 | |
500 mg | In stock | $ 3,970.00 |
Description | NRX-252114 (NRX252114) induces degradation of mutant β-catenin NRX-252114 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP, and is able to enhance the binding of pSer33/S37A β-catenin to β-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. Kd is 0.4 nM. |
Targets&IC50 | β-catenin-β-TrCP:6.5 nM(EC50), β-catenin-β-TrCP:0.4 nM(Kd) |
Synonyms | NRX252114, NRX 252114 |
Molecular Weight | 510.32 |
Formula | C22H12Cl2F3N3O2S |
CAS No. | 2763260-39-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (97.98 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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NRX-252114 2763260-39-3 Cytoskeletal Signaling Stem Cells Wnt/beta-catenin NRX252114 NRX 252114 inhibitor inhibit