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J-2156 TFA

Name: J-2156 TFA
Brand: TargetMol
SKU: T64113
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T64113Cas No. 2387505-73-7

Alias J2156 TFA, J 2156 TFA

J-2156 TFA is a selective SST4 receptor (somatostatin receptor type 4) agonist with IC50 values of 0.05 nM and 0.07 nM for human and rat SST4 receptors respectively. It exhibits anti-inflammatory and analgesic effects while reducing pERK levels.

J-2156 TFA

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Catalog No. T64113Alias J2156 TFA, J 2156 TFACas No. 2387505-73-7

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$64	-	In Stock
5 mg	Preferential	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	J-2156 TFA is a selective SST4 receptor (somatostatin receptor type 4) agonist with IC50 values of 0.05 nM and 0.07 nM for human and rat SST4 receptors respectively. It exhibits anti-inflammatory and analgesic effects while reducing pERK levels.
Targets&IC50	SST4 (human):0.05 nM, SST4 (rat):0.07 nM
In vitro	J-2156 TFA exhibits nanomolar affinity (Ki=1.2 nM) for the homo sapiens somatostatin receptor subtype 4 (hsst4), with over 400-fold selectivity for this subtype compared to other somatostatin receptors [2].
In vivo	J-2156 TFA (1-10 mg/kg, 3 hours) was administered as a single intraperitoneal injection, which produced anti-parazacco spilurus subsp. spilurus chronic pain effects in both ipsilateral and contralateral sides of BCIBP rats [1].
Synonyms	J2156 TFA, J 2156 TFA

Chemical Properties

Molecular Weight	582.6
Formula	C₂₆H₂₉F₃N₄O₆S
Cas No.	2387505-73-7
Smiles	OC(=O)C(F)(F)F.Cc1ccc(c2ccccc12)S(=O)(=O)N[C@@H](CCN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 80 mg/mL (137.32 mM), Sonication is recommended.

DMSO: 80 mg/mL (137.32 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (5.66 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7164 mL	8.5822 mL	17.1644 mL	85.8222 mL
5 mM	0.3433 mL	1.7164 mL	3.4329 mL	17.1644 mL
10 mM	0.1716 mL	0.8582 mL	1.7164 mL	8.5822 mL
20 mM	0.0858 mL	0.4291 mL	0.8582 mL	4.2911 mL
50 mM	0.0343 mL	0.1716 mL	0.3433 mL	1.7164 mL
100 mM	0.0172 mL	0.0858 mL	0.1716 mL	0.8582 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

J-2156 TFA

J-2156 TFA

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