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(-)-Agelastatin A
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Catalog No. T26358Cas No. 152406-28-5
Alias AglA, Agelastatin A
(-)-Agelastatin A is a member of the pyrrole-aminoimidazole marine alkaloid (PAI) family, capable of inhibiting β-catenin, GSK-3β, and osteopontin (OPN), exhibiting antiproliferative activity against various cancers such as leukaemia and breast cancer, and possessing a certain ability to penetrate the central nervous system (CNS).
(-)-Agelastatin A
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Purity: 99.01%
Catalog No. T26358Alias AglA, Agelastatin ACas No. 152406-28-5
(-)-Agelastatin A is a member of the pyrrole-aminoimidazole marine alkaloid (PAI) family, capable of inhibiting β-catenin, GSK-3β, and osteopontin (OPN), exhibiting antiproliferative activity against various cancers such as leukaemia and breast cancer, and possessing a certain ability to penetrate the central nervous system (CNS).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $490 | - | In Stock | |
| 5 mg | $1,090 | - | In Stock | |
| 10 mg | $1,480 | - | In Stock | |
| 25 mg | $2,230 | - | In Stock | |
| 50 mg | $2,950 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.01%
ee:97.15%
Appearance:Solid
Color:White to Brown
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | (-)-Agelastatin A is a member of the pyrrole-aminoimidazole marine alkaloid (PAI) family, capable of inhibiting β-catenin, GSK-3β, and osteopontin (OPN), exhibiting antiproliferative activity against various cancers such as leukaemia and breast cancer, and possessing a certain ability to penetrate the central nervous system (CNS). |
| Targets&IC50 | Jurkat cells:74 nM, U-937 cells:67 nM, BT-549 cells:278 nM, IMR90 cells:1.11 μM, HL-60 cells:138 nM, CEM cells:20 nM, CA46 cells:187 nM, HeLa cells:708 nM, Daudi cells:20 nM, A549 cells:1.05 μM |
| In vitro | Methods: Agelastatin A (0-2 μM, 48 h) was used to treat U-937, HeLa, A549, BT549 and IMR90 cells, and the IC50 values at 48 hours were determined by MTS. Results: The IC50 values of U-937, HeLa, A549, BT549 and IMR90 cells were 67 nM, 708 nM, 1.05 μM, 278 nM and 1.11 μM, respectively. Methods: CEM, Jurkat, Daudi, HL-60 and CA46 cells were treated with Agelastatin A (0-1 μM, 48 h). The IC50 values at 48 h were determined by MTS assay. Results: The IC50 values of CEM, Jurkat, Daudi, HL-60 and CA46 cells were 20, 74, 20, 138 and 187 nM, respectively. [1] |
| Synonyms | AglA, Agelastatin A |
| Molecular Weight | 341.16 |
| Formula | C12H13BrN4O3 |
| Cas No. | 152406-28-5 |
| Smiles | BrC=1N2[C@]3([C@]([C@]4([C@@](O)(C3)N(C)C(=O)N4)[H])(NC(=O)C2=CC1)[H])[H] |
| Relative Density. | 2.24 g/cm3 (Predicted) |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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