Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SRI-37240 is a powerful inhibitor of premature termination codons (PTCs). It effectively suppresses CFTR nonsense mutations and induces changes in cellular translation termination at PTCs in HEK293T cells. Additionally, when combined with G418, SRI-37240 restores CFTR function in primary bronchial epithelial cells [1].
Pack Size | Availability | Price/USD | Quantity |
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2 mg | 5 days | $ 58.00 |
Description | SRI-37240 is a powerful inhibitor of premature termination codons (PTCs). It effectively suppresses CFTR nonsense mutations and induces changes in cellular translation termination at PTCs in HEK293T cells. Additionally, when combined with G418, SRI-37240 restores CFTR function in primary bronchial epithelial cells [1]. |
In vitro | SRI-37240 (1, 3, 10, and 30 μM; 48 h) elicits concentration-dependent enhancements in CFTR-dependent chloride conductance, which is activated by Forskolin and inhibited by CFTR Inh-172 [1]. At a concentration of 10 μM over 72 h, it significantly elevates levels of both the mature, fully glycosylated, and the immature forms of the CFTR protein in 16HBEge cells, especially when administered alongside G418 (100 μM) [1]. Additionally, at 10 μM for 24 h, SRI-37240 changes cellular translation termination at premature termination codons (PTCs) in HEK293T cells and boosts overall ribosome densities at normal stop codons, without impacting ribosome densities in 3'-UTRs [1]. This compound also restores CFTR function in primary bronchial epithelial cells under combined treatment with G418 over 72 h [1]. Western Blot Analysis reveals that, at 10 μM for 24 h, there is a noticeable increase in both the mature (Band C) and immature (Band B) forms of CFTR protein in CFTR-G542X 16HBEge cells when used with G418 (100 μM) [1]. |
Molecular Weight | 385.46 |
Formula | C24H23N3O2 |
CAS No. | 883956-47-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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SRI-37240 883956-47-6 inhibitor inhibit