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BSJ-03-204

Name: BSJ-03-204
Brand: TargetMol
SKU: T30600
Rating: 4.5 (1 reviews)

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Catalog No. T30600Cas No. 2349356-09-6

Alias BSJ03204

BSJ-03-204 is a rationally designed PROTAC composed of cereblon and CDK ligands that functions as a potent and selective palbociclib-based CDK4/6 dual degrader, achieving nanomolar inhibition of CDK4/D1 and CDK6/D1 complexes without inducing IKZF1/3 degradation, BSJ-03-204 exhibit strong anticancer activity with improved selectivity.

BSJ-03-204

😃Good

Catalog No. T30600Alias BSJ03204Cas No. 2349356-09-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$817	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	BSJ-03-204 is a rationally designed PROTAC composed of cereblon and CDK ligands that functions as a potent and selective palbociclib-based CDK4/6 dual degrader, achieving nanomolar inhibition of CDK4/D1 and CDK6/D1 complexes without inducing IKZF1/3 degradation, BSJ-03-204 exhibit strong anticancer activity with improved selectivity.
Targets&IC50	CDK4-CyclinD1:26.9 nM, CDK6-CyclinD1:10.4 nM
In vitro	In wild-type cells, treatment with BSJ-03-204 (0.1-5 μM) for 4 hours induced the rapid degradation of CDK4/6 without affecting IKZF1/3 levels. In Mantle Cell Lymphoma (MCL) cell lines, the compound demonstrated potent anti-proliferative activity across a broad concentration range (0.0001-100 μM) over 3 to 4 days [1].
Synonyms	BSJ03204

Chemical Properties

Molecular Weight	832.9
Formula	C₄₃H₄₈N₁₀O₈
Cas No.	2349356-09-6
Smiles	O=C(NCCCCN1CCN(C2=CN=C(C=C2)NC=3N=CC4=C(N3)N(C(=O)C(C(=O)C)=C4C)C5CCCC5)CC1)COC6=CC=CC=7C(=O)N(C(=O)C67)C8C(=O)NC(=O)CC8
Relative Density.	1.397 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (96.05 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2006 mL	6.0031 mL	12.0062 mL	60.0312 mL
5 mM	0.2401 mL	1.2006 mL	2.4012 mL	12.0062 mL
10 mM	0.1201 mL	0.6003 mL	1.2006 mL	6.0031 mL
20 mM	0.0600 mL	0.3002 mL	0.6003 mL	3.0016 mL
50 mM	0.0240 mL	0.1201 mL	0.2401 mL	1.2006 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc