Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

BSJ-03-204

Name: BSJ-03-204
Brand: TargetMol
SKU: T30600
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T30600Cas No. 2349356-09-6

Alias BSJ03204

BSJ-03-204 is a rationally designed PROTAC composed of cereblon and CDK ligands that functions as a potent and selective palbociclib-based CDK4/6 dual degrader, achieving nanomolar inhibition of CDK4/D1 and CDK6/D1 complexes without inducing IKZF1/3 degradation, BSJ-03-204 exhibit strong anticancer activity with improved selectivity.

BSJ-03-204

😃Good

Catalog No. T30600Alias BSJ03204Cas No. 2349356-09-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$817	35 days	35 days

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Resource Download

Product Introduction

Bioactivity

Description	BSJ-03-204 is a rationally designed PROTAC composed of cereblon and CDK ligands that functions as a potent and selective palbociclib-based CDK4/6 dual degrader, achieving nanomolar inhibition of CDK4/D1 and CDK6/D1 complexes without inducing IKZF1/3 degradation, BSJ-03-204 exhibit strong anticancer activity with improved selectivity.
Targets&IC50	CDK4-CyclinD1:26.9 nM, CDK6-CyclinD1:10.4 nM
Synonyms	BSJ03204

Chemical Properties

Molecular Weight	832.9
Formula	C₄₃H₄₈N₁₀O₈
Cas No.	2349356-09-6
Smiles	O=C(NCCCCN1CCN(C2=CN=C(C=C2)NC=3N=CC4=C(N3)N(C(=O)C(C(=O)C)=C4C)C5CCCC5)CC1)COC6=CC=CC=7C(=O)N(C(=O)C67)C8C(=O)NC(=O)CC8
Relative Density.	1.397 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (96.05 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2006 mL	6.0031 mL	12.0062 mL	60.0312 mL
5 mM	0.2401 mL	1.2006 mL	2.4012 mL	12.0062 mL
10 mM	0.1201 mL	0.6003 mL	1.2006 mL	6.0031 mL
20 mM	0.0600 mL	0.3002 mL	0.6003 mL	3.0016 mL
50 mM	0.0240 mL	0.1201 mL	0.2401 mL	1.2006 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc