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TDO-IN-1

Name: TDO-IN-1
Brand: TargetMol
SKU: T61202
Price: 117 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T61202Cas No. 2490672-92-7

TDO-IN-1 is an orally active, potent, and selective inhibitor of tryptophan 2,3-dioxygenase (TDO), inhibiting indoleamine-2,3-dioxygenase, with antitumor activity that reverses local immune tolerance in tumor tissues.

TDO-IN-1

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Purity: 99.86%

Catalog No. T61202Cas No. 2490672-92-7

Pack Size	Price	Availability
1 mg	$117	In Stock
2 mg	$169	In Stock
5 mg	$289	In Stock
10 mg	$455	In Stock
25 mg	$892	In Stock
50 mg	$1,450	In Stock
100 mg	$1,970	In Stock

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Purity:99.86%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	TDO-IN-1 is an orally active, potent, and selective inhibitor of tryptophan 2,3-dioxygenase (TDO), inhibiting indoleamine-2,3-dioxygenase, with antitumor activity that reverses local immune tolerance in tumor tissues.
Targets&IC50	TDO:0.62 μM, H22 cells:1.34 μM, HepG2 cells:0.54 μM, Hepa1-6:5.08 μM, Jurkat cells:7.25 μM, MOLM-13:3.43 μM, B16 cells:37.39 μM
In vitro	TDO-IN-1 (HT-28) exhibits significant tumoricidal effects on various tumor lines at concentrations ranging from 0 to 100 μM over 24 hours, with IC50 values of 0.54 μM (HepG2), 5.08 μM (Hepa1-6), 1.34 μM (H22), 37.39 μM (B16), 3.43 μM (MOLM-13), and 7.25 μM (Jurkat)[1]. Additionally, TDO-IN-1 (0-100 μM; 24 h) shows minimal cytotoxicity against normal cells (HEK 293) at concentrations below 10 μM[1].
In vivo	Administered orally at a dose of 25 mg/kg once daily for 9 days, TDO-IN-1 (HT-28) enhances the efficacy of tumor immunotherapy in CT26 tumors expressing TDO. This treatment substantially inhibits the proliferation of CT26 tumors in mice[1].

Chemical Properties

Molecular Weight	350.3
Formula	C₁₆H₁₃F₃N₄O₂
Cas No.	2490672-92-7
Smiles	N(CC1=C(N(=O)=O)C=C(C)C=C1)C2=C3C(=CC(C(F)(F)F)=C2)NN=C3
Color	Orange
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (171.28 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8547 mL	14.2735 mL	28.5470 mL	142.7348 mL
5 mM	0.5709 mL	2.8547 mL	5.7094 mL	28.5470 mL
10 mM	0.2855 mL	1.4273 mL	2.8547 mL	14.2735 mL
20 mM	0.1427 mL	0.7137 mL	1.4273 mL	7.1367 mL
50 mM	0.0571 mL	0.2855 mL	0.5709 mL	2.8547 mL
100 mM	0.0285 mL	0.1427 mL	0.2855 mL	1.4273 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc