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Bosutinib hydrate

Catalog No. T63875 CAS 918639-08-4

Synonyms: PF-5208763 hydrate, PF-05208763 hydrate, SKI-606 hydrate

Bosutinib hydrate (SKI-606 hydrate) is an orally active and potent dual kinase inhibitor of BCR-ABL and Src tyrosine kinases for the study of Philadelphia Chromosome Positive Chronic Granulocytic Leukemia.

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Bosutinib hydrate, CAS 918639-08-4

Pack Size	Availability	Price/USD
5 mg	In stock	$ 33.00
10 mg	In stock	$ 53.00
25 mg	In stock	$ 79.00
50 mg	In stock	$ 108.00
100 mg	In stock	$ 162.00
500 mg	In stock	$ 328.00

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Purity: 99.87%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Bosutinib hydrate (SKI-606 hydrate) is an orally active and potent dual kinase inhibitor of BCR-ABL and Src tyrosine kinases for the study of Philadelphia Chromosome Positive Chronic Granulocytic Leukemia.
Targets&IC50	Csk:314 nmol/L, Abl kinase:2.4 nmol/L
In vitro	Bosutinib hydrate(SKI-606)was a inhibitor of two Src-related kinases (i.e., Fgr and Lyn with IC50s of 0.174 and 0.850 nmol/L, respectively)[2].
In vivo	Administration of Bosutinib hydrate(SKI-606) at doses of 75 mg/kg twice daily or 150 mg/kg once daily can promote complete regression of human K562 xenografts for up to 40 days[2].

Synonyms	PF-5208763 hydrate, PF-05208763 hydrate, SKI-606 hydrate
Molecular Weight	548.46
Formula	C26H31Cl2N5O4
CAS No.	918639-08-4

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (145.86 mM), Sonication is recommended.

References and Literature

1. Jorge E Cortes, et al. Bosutinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: results from the BELA trial. J Clin Oncol. 2012 Oct 1;30(28):3486-92. 2. Miriam Puttini, et al. In vitro and in vivo activity of SKI-606, a novel Src-Abl inhibitor, against imatinib-resistant Bcr-Abl+ neoplastic cells. Cancer Res. 2006 Dec 1;66(23):11314-22.

Related Products

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Imatinib Radotinib BCR-ABL-IN-7 CGP77675 Lyn-IN-1 Nilotinib hydrochloride GNF-5 Silybin B

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Bosutinib hydrate 918639-08-4 Angiogenesis Cytoskeletal Signaling Tyrosine Kinase/Adaptors Bcr-Abl Src PF-5208763 hydrate PF-05208763 hydrate SKI-606 hydrate inhibitor inhibit

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