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Bosutinib hydrate

Name: Bosutinib hydrate
Brand: TargetMol
SKU: T63875
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T63875Cas No. 918639-08-4

Alias SKI-606 hydrate, PF-5208763 hydrate, PF-05208763 hydrate

Bosutinib hydrate (SKI-606 hydrate) is an orally active and potent dual kinase inhibitor of BCR-ABL and Src tyrosine kinases for the study of Philadelphia Chromosome Positive Chronic Granulocytic Leukemia.

Bosutinib hydrate

🥰Excellent

Purity: 99.87%

Catalog No. T63875Alias SKI-606 hydrate, PF-5208763 hydrate, PF-05208763 hydrateCas No. 918639-08-4

Pack Size	Price	Availability
5 mg	$33	In Stock
10 mg	$53	In Stock
25 mg	$79	In Stock
50 mg	$108	In Stock
100 mg	$162	In Stock
500 mg	$328	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.87%

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	Bosutinib hydrate (SKI-606 hydrate) is an orally active and potent dual kinase inhibitor of BCR-ABL and Src tyrosine kinases for the study of Philadelphia Chromosome Positive Chronic Granulocytic Leukemia.
Targets&IC50	Abl kinase:2.4 nmol/L, Csk:314 nmol/L
In vitro	Bosutinib hydrate(SKI-606)was a inhibitor of two Src-related kinases (i.e., Fgr and Lyn with IC50s of 0.174 and 0.850 nmol/L, respectively)[2].
In vivo	Administration of Bosutinib hydrate(SKI-606) at doses of 75 mg/kg twice daily or 150 mg/kg once daily can promote complete regression of human K562 xenografts for up to 40 days[2].
Synonyms	SKI-606 hydrate, PF-5208763 hydrate, PF-05208763 hydrate

Chemical Properties

Molecular Weight	548.46
Formula	C₂₆H₃₁Cl₂N₅O₄
Cas No.	918639-08-4
Smiles	O.COc1cc(Nc2c(cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)C#N)c(Cl)cc1Cl
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (145.86 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8233 mL	9.1164 mL	18.2329 mL	91.1644 mL
5 mM	0.3647 mL	1.8233 mL	3.6466 mL	18.2329 mL
10 mM	0.1823 mL	0.9116 mL	1.8233 mL	9.1164 mL
20 mM	0.0912 mL	0.4558 mL	0.9116 mL	4.5582 mL
50 mM	0.0365 mL	0.1823 mL	0.3647 mL	1.8233 mL
100 mM	0.0182 mL	0.0912 mL	0.1823 mL	0.9116 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc