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Piperazine Erastin

Name: Piperazine Erastin
Brand: TargetMol
SKU: T16540
Price: 88 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16540Cas No. 1538593-71-3

Piperazine erastin, an analog of erastin, induces ferroptosis, an iron-dependent form of non-apoptotic cell death.

Piperazine Erastin

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Purity: 99.52%

Catalog No. T16540Cas No. 1538593-71-3

Piperazine erastin, an analog of erastin, induces ferroptosis, an iron-dependent form of non-apoptotic cell death.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$88	In Stock	In Stock
5 mg	$177	In Stock	In Stock
10 mg	$297	In Stock	In Stock
25 mg	$596	In Stock	In Stock
50 mg	$977	In Stock	In Stock
100 mg	$1,290	In Stock	In Stock
200 mg	$1,770	In Stock	In Stock
500 mg	$2,630	-	In Stock
1 mL x 10 mM (in DMSO)	$253	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.52%

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COA HPLC HNMR LCMS

Product Introduction

Bioactivity

Description	Piperazine erastin, an analog of erastin, induces ferroptosis, an iron-dependent form of non-apoptotic cell death.
In vitro	Piperazine erastin is affected similarly by cell death modulators as erastin and displays a distinct pattern from other non-FIN lethal compounds. Piperazine erastin is a more effective analog of erastin which is more water-soluble (0.086 mM for erastin versus 1.4 mM for piperazine erastin) and more metabolically stable [1].
In vivo	A significant delay in tumor growth is observed in the piperazine erastin-treated group compared to the vehicle-treated group, in the xenograft mouse model. Ptgs2 is upregulated in mouse liver with piperazine erastin (10 or 60 mg/kg) administration[1].

Chemical Properties

Molecular Weight	645.19
Formula	C₃₅H₄₁ClN₆O₄
Cas No.	1538593-71-3
Smiles	C(C=1N(C(=O)C=2C(N1)=CC=CC2)C3=C(OC(C)C)C=CC(CN4CCNCC4)=C3)N5CCN(C(COC6=CC=C(Cl)C=C6)=O)CC5
Relative Density.	1.31 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 132.5 mg/mL (205.37 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.1 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5499 mL	7.7497 mL	15.4993 mL	77.4966 mL
5 mM	0.3100 mL	1.5499 mL	3.0999 mL	15.4993 mL
10 mM	0.1550 mL	0.7750 mL	1.5499 mL	7.7497 mL
20 mM	0.0775 mL	0.3875 mL	0.7750 mL	3.8748 mL
50 mM	0.0310 mL	0.1550 mL	0.3100 mL	1.5499 mL
100 mM	0.0155 mL	0.0775 mL	0.1550 mL	0.7750 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc