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AMPA receptor modulator-2

Name: AMPA receptor modulator-2
Brand: TargetMol
SKU: T37734
Price: 125 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T37734Cas No. 2034181-36-5

AMPA receptor modulator-2 (Example 134) is an AMPA receptor modulator with a pIC50 of 10.1 for TARPγ2 dependent AMPA receptor[1]. pIC50 = -lgIC50. [1]. BERRY CYNTHIA G B (US), et al. AZABENZIMIDAZOLES AND THEIR USE AS AMPA RECEPTOR MODULATORS. Patent. WO2016176460.

AMPA receptor modulator-2

🥰Excellent

Purity: 99.8%

Catalog No. T37734Cas No. 2034181-36-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$125	In Stock	In Stock
5 mg	$313	In Stock	In Stock
10 mg	$413	In Stock	In Stock
25 mg	$662	In Stock	In Stock
50 mg	$953	In Stock	In Stock
100 mg	$1,320	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$345	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.8%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	AMPA receptor modulator-2 (Example 134) is an AMPA receptor modulator with a pIC50 of 10.1 for TARPγ2 dependent AMPA receptor[1]. pIC50 = -lgIC50. [1]. BERRY CYNTHIA G B (US), et al. AZABENZIMIDAZOLES AND THEIR USE AS AMPA RECEPTOR MODULATORS. Patent. WO2016176460.
Targets&IC50	AMPA:10.1(pIC50)

Chemical Properties

Molecular Weight	404.29
Formula	C₁₅H₆F₆N₄OS
Cas No.	2034181-36-5
Smiles	FC(F)(F)c1nc2ccc(nc2n1-c1ccc2[nH]c(=O)sc2c1)C(F)(F)F
Relative Density.	1.79 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 250 mg/mL (618.37 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (12.37 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4735 mL	12.3674 mL	24.7347 mL	123.6736 mL
5 mM	0.4947 mL	2.4735 mL	4.9469 mL	24.7347 mL
10 mM	0.2473 mL	1.2367 mL	2.4735 mL	12.3674 mL
20 mM	0.1237 mL	0.6184 mL	1.2367 mL	6.1837 mL
50 mM	0.0495 mL	0.2473 mL	0.4947 mL	2.4735 mL
100 mM	0.0247 mL	0.1237 mL	0.2473 mL	1.2367 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc