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AMPA receptor modulator-2

🥰Excellent
Catalog No. T37734Cas No. 2034181-36-5

AMPA receptor modulator-2 (Example 134) is an AMPA receptor modulator with a pIC50 of 10.1 for TARPγ2 dependent AMPA receptor[1]. pIC50 = -lgIC50. [1]. BERRY CYNTHIA G B (US), et al. AZABENZIMIDAZOLES AND THEIR USE AS AMPA RECEPTOR MODULATORS. Patent. WO2016176460.

AMPA receptor modulator-2

AMPA receptor modulator-2

🥰Excellent
Purity: 99.8%
Catalog No. T37734Cas No. 2034181-36-5
AMPA receptor modulator-2 (Example 134) is an AMPA receptor modulator with a pIC50 of 10.1 for TARPγ2 dependent AMPA receptor[1]. pIC50 = -lgIC50. [1]. BERRY CYNTHIA G B (US), et al. AZABENZIMIDAZOLES AND THEIR USE AS AMPA RECEPTOR MODULATORS. Patent. WO2016176460.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$125In StockIn Stock
5 mg$313In StockIn Stock
10 mg$413In StockIn Stock
25 mg$662In StockIn Stock
50 mg$953In StockIn Stock
100 mg$1,320In StockIn Stock
1 mL x 10 mM (in DMSO)$345In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.8%
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Product Introduction

Bioactivity
Description
AMPA receptor modulator-2 (Example 134) is an AMPA receptor modulator with a pIC50 of 10.1 for TARPγ2 dependent AMPA receptor[1]. pIC50 = -lgIC50. [1]. BERRY CYNTHIA G B (US), et al. AZABENZIMIDAZOLES AND THEIR USE AS AMPA RECEPTOR MODULATORS. Patent. WO2016176460.
Targets&IC50
AMPA:10.1(pIC50)
Chemical Properties
Molecular Weight404.29
FormulaC15H6F6N4OS
Cas No.2034181-36-5
SmilesFC(F)(F)c1nc2ccc(nc2n1-c1ccc2[nH]c(=O)sc2c1)C(F)(F)F
Relative Density.1.79 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: < 0.1 mg/mL (insoluble)
DMSO: 250 mg/mL (618.37 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (12.37 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4735 mL12.3674 mL24.7347 mL123.6736 mL
5 mM0.4947 mL2.4735 mL4.9469 mL24.7347 mL
10 mM0.2473 mL1.2367 mL2.4735 mL12.3674 mL
20 mM0.1237 mL0.6184 mL1.2367 mL6.1837 mL
50 mM0.0495 mL0.2473 mL0.4947 mL2.4735 mL
100 mM0.0247 mL0.1237 mL0.2473 mL1.2367 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TARPγIonotropic glutamate receptorsInhibitorinhibitiGluRAMPA receptor modulator-2AMPA receptor modulator2AMPA receptor modulator 2AMPA
Related Tags: buy AMPA receptor modulator-2 | purchase AMPA receptor modulator-2 | AMPA receptor modulator-2 cost | order AMPA receptor modulator-2 | AMPA receptor modulator-2 chemical structure | AMPA receptor modulator-2 formula | AMPA receptor modulator-2 molecular weight
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