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Chromomycin A3

Name: Chromomycin A3
Brand: TargetMol
SKU: T10810
Rating: 4.5 (1 reviews)

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Catalog No. T10810Cas No. 7059-24-7

Chromomycin A3 is an antibiotic produced by Streptomyces sp that binds to gc-rich DNA sequences in the presence of divalent cations and inhibits DNA replication and transcription; it is also used as a fluorescent DNA stain and assay; and it has anticancer activity against diseases such as Hodgkin's, lung adenocarcinomas, melanomas, and breast cancer.

Chromomycin A3

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Catalog No. T10810Cas No. 7059-24-7

Pack Size	Price	Availability
1 mg	TBD	35 days
5 mg	TBD	35 days
10 mg	TBD	35 days

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Chromomycin A3 is an antibiotic produced by Streptomyces sp that binds to gc-rich DNA sequences in the presence of divalent cations and inhibits DNA replication and transcription; it is also used as a fluorescent DNA stain and assay; and it has anticancer activity against diseases such as Hodgkin's, lung adenocarcinomas, melanomas, and breast cancer.
Targets&IC50	MIA PaCa-2 cells:1.34 nM, AsPC-1 cells:2.01 nM, BxPC-3 cells:1.15 nM
In vitro	Chromomycin A3 showed strong antiproliferative effects in human pancreatic cancer cells AsPC-1, MIA PaCa-2, and BxPC-3 (IC₅₀: 2.01, 1.34, and 1.15 nM, respectively; 72 h treatment), and induced apoptosis at 5 nM with increased cleaved caspase-3 and PARP[1].
In vivo	In a MIA PaCa-2 xenograft model, intraperitoneal injection of Chromomycin A3 (0.5 mg/kg, once daily for 14 days) reduced tumor volume by over 60% without notable toxicity; tumor tissues showed reduced Ki-67 and increased cleaved caspase-3[1].

Chemical Properties

Molecular Weight	1183.24
Formula	C₅₇H₈₂O₂₆
Cas No.	7059-24-7
Smiles	O=C1C=2C(C[C@@]([C@@H](C([C@H]([C@@H](C)O)O)=O)OC)([C@@H]1O[C@H]3C[C@@H](O[C@H]4C[C@@H](O[C@H]5C[C@](C)(O)[C@@H](OC(C)=O)[C@H](C)O5)[C@H](O)[C@@H](C)O4)[C@H](O)[C@@H](C)O3)[H])=CC=6C(C2O)=C(O)C(C)=C(O[C@H]7C[C@@H](O[C@@H]8C[C@@H](O)[C@@H](OC)[C@@H](C)O8)[C@@H](OC(C)=O)[C@@H](C)O7)C6
Relative Density.	1.43g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80.00 mg/mL (67.61 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8451 mL	4.2257 mL	8.4514 mL	42.2569 mL
5 mM	0.1690 mL	0.8451 mL	1.6903 mL	8.4514 mL
10 mM	0.0845 mL	0.4226 mL	0.8451 mL	4.2257 mL
20 mM	0.0423 mL	0.2113 mL	0.4226 mL	2.1128 mL
50 mM	0.0169 mL	0.0845 mL	0.1690 mL	0.8451 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc