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Chromomycin A3

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Catalog No. T10810Cas No. 7059-24-7

Chromomycin A3 is an antibiotic produced by Streptomyces sp that binds to gc-rich DNA sequences in the presence of divalent cations and inhibits DNA replication and transcription; it is also used as a fluorescent DNA stain and assay; and it has anticancer activity against diseases such as Hodgkin's, lung adenocarcinomas, melanomas, and breast cancer.

Chromomycin A3

Chromomycin A3

😃Good
Catalog No. T10810Cas No. 7059-24-7
Chromomycin A3 is an antibiotic produced by Streptomyces sp that binds to gc-rich DNA sequences in the presence of divalent cations and inhibits DNA replication and transcription; it is also used as a fluorescent DNA stain and assay; and it has anticancer activity against diseases such as Hodgkin's, lung adenocarcinomas, melanomas, and breast cancer.
Pack SizePriceAvailabilityQuantity
1 mgTBD35 days
5 mgTBD35 days
10 mgTBD35 days
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Product Introduction

Bioactivity
Description
Chromomycin A3 is an antibiotic produced by Streptomyces sp that binds to gc-rich DNA sequences in the presence of divalent cations and inhibits DNA replication and transcription; it is also used as a fluorescent DNA stain and assay; and it has anticancer activity against diseases such as Hodgkin's, lung adenocarcinomas, melanomas, and breast cancer.
Targets&IC50
MIA PaCa-2 cells:1.34 nM, AsPC-1 cells:2.01 nM, BxPC-3 cells:1.15 nM
In vitro
Chromomycin A3 showed strong antiproliferative effects in human pancreatic cancer cells AsPC-1, MIA PaCa-2, and BxPC-3 (IC₅₀: 2.01, 1.34, and 1.15 nM, respectively; 72 h treatment), and induced apoptosis at 5 nM with increased cleaved caspase-3 and PARP[1].
In vivo
In a MIA PaCa-2 xenograft model, intraperitoneal injection of Chromomycin A3 (0.5 mg/kg, once daily for 14 days) reduced tumor volume by over 60% without notable toxicity; tumor tissues showed reduced Ki-67 and increased cleaved caspase-3[1].
Chemical Properties
Molecular Weight1183.24
FormulaC57H82O26
Cas No.7059-24-7
SmilesO=C1C=2C(C[C@@]([C@@H](C([C@H]([C@@H](C)O)O)=O)OC)([C@@H]1O[C@H]3C[C@@H](O[C@H]4C[C@@H](O[C@H]5C[C@](C)(O)[C@@H](OC(C)=O)[C@H](C)O5)[C@H](O)[C@@H](C)O4)[C@H](O)[C@@H](C)O3)[H])=CC=6C(C2O)=C(O)C(C)=C(O[C@H]7C[C@@H](O[C@@H]8C[C@@H](O)[C@@H](OC)[C@@H](C)O8)[C@@H](OC(C)=O)[C@@H](C)O7)C6
Relative Density.1.43g/cm3
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80.00 mg/mL (67.61 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.8451 mL4.2257 mL8.4514 mL42.2569 mL
5 mM0.1690 mL0.8451 mL1.6903 mL8.4514 mL
10 mM0.0845 mL0.4226 mL0.8451 mL4.2257 mL
20 mM0.0423 mL0.2113 mL0.4226 mL2.1128 mL
50 mM0.0169 mL0.0845 mL0.1690 mL0.8451 mL

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