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Chromomycin A3

Name: Chromomycin A3
Brand: TargetMol
SKU: T10810
Rating: 4.5 (1 reviews)

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Catalog No. T10810Cas No. 7059-24-7

Chromomycin A3 is an antibiotic produced by Streptomyces sp that binds to gc-rich DNA sequences in the presence of divalent cations and inhibits DNA replication and transcription; it is also used as a fluorescent DNA stain and assay; and it has anticancer activity against diseases such as Hodgkin's, lung adenocarcinomas, melanomas, and breast cancer.

Chromomycin A3

😃Good

Catalog No. T10810Cas No. 7059-24-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$178	35 days	35 days
5 mg	$490	35 days	35 days
10 mg	$888	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:Yellow

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COA

Product Introduction

Bioactivity

Description	Chromomycin A3 is an antibiotic produced by Streptomyces sp that binds to gc-rich DNA sequences in the presence of divalent cations and inhibits DNA replication and transcription; it is also used as a fluorescent DNA stain and assay; and it has anticancer activity against diseases such as Hodgkin's, lung adenocarcinomas, melanomas, and breast cancer.
Targets&IC50	MIAPaCa2 cells:1.34 nM, BxPC-3 cells:1.15 nM, AsPC1 cells:2.01 nM
In vitro	Chromomycin A3 showed strong antiproliferative effects in human pancreatic cancer cells AsPC-1, MIA PaCa-2, and BxPC-3 (IC₅₀: 2.01, 1.34, and 1.15 nM, respectively; 72 h treatment), and induced apoptosis at 5 nM with increased cleaved caspase-3 and PARP[1].
In vivo	In a MIA PaCa-2 xenograft model, intraperitoneal injection of Chromomycin A3 (0.5 mg/kg, once daily for 14 days) reduced tumor volume by over 60% without notable toxicity; tumor tissues showed reduced Ki-67 and increased cleaved caspase-3[1].

Chemical Properties

Molecular Weight	1183.24
Formula	C₅₇H₈₂O₂₆
Cas No.	7059-24-7
Smiles	O=C1C=2C(C[C@@]([C@@H](C([C@H]([C@@H](C)O)O)=O)OC)([C@@H]1O[C@H]3C[C@@H](O[C@H]4C[C@@H](O[C@H]5C[C@](C)(O)[C@@H](OC(C)=O)[C@H](C)O5)[C@H](O)[C@@H](C)O4)[C@H](O)[C@@H](C)O3)[H])=CC=6C(C2O)=C(O)C(C)=C(O[C@H]7C[C@@H](O[C@@H]8C[C@@H](O)[C@@H](OC)[C@@H](C)O8)[C@@H](OC(C)=O)[C@@H](C)O7)C6
Relative Density.	1.43g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (67.61 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8451 mL	4.2257 mL	8.4514 mL	42.2569 mL
5 mM	0.1690 mL	0.8451 mL	1.6903 mL	8.4514 mL
10 mM	0.0845 mL	0.4226 mL	0.8451 mL	4.2257 mL
20 mM	0.0423 mL	0.2113 mL	0.4226 mL	2.1128 mL
50 mM	0.0169 mL	0.0845 mL	0.1690 mL	0.8451 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc