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Anti-TREM-1 Antibody (9L702)
😃Good
Catalog No. TMAY-00923
Alias triggering receptor expressed on myeloid cells 1
Anti-TREM-1 Antibody (9L702) is a Mouse antibody targeting TREM-1. Anti-TREM-1 Antibody (9L702) can be used in ELISA(Det).
Anti-TREM-1 Antibody (9L702)
Anti-TREM-1 Antibody (9L702)
😃Good
Catalog No. TMAY-00923Alias triggering receptor expressed on myeloid cells 1
Anti-TREM-1 Antibody (9L702) is a Mouse antibody targeting TREM-1. Anti-TREM-1 Antibody (9L702) can be used in ELISA(Det).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $69 | 7-10 days | |
| 100 μL | $199 | 7-10 days |
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Product Introduction
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Antigen Details
Chemical Properties
| Description | Anti-TREM-1 Antibody (9L702) is a Mouse antibody targeting TREM-1. Anti-TREM-1 Antibody (9L702) can be used in ELISA(Det). |
| Alias | triggering receptor expressed on myeloid cells 1 |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 9L702 |
| Reactivity | Human |
| Application | ELISA(Det) |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human TREM-1 / TREM1 (rh TREM-1 / TREM1; TMPY-01774; NP_061113.1; Met1-Arg200). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | TREM1 (triggering receptor expressed on myeloid cells) is a type I transmembrane protein with a single Ig-like domain, and is selectively expressed on blood neutrophils and a subset of monocytes. As a member of the growing family of receptors related to NK cell receptors, TREM1 activates downstream signaling events with the help of an adapter protein called DAP12. Expression of TREM1 is up-regulated by bacterial LPS, a ligand for TLR4, as well as lipoteichoic acid. Although its natural ligand has not been identified, engagement of TREM1 with agonist mAbs triggers secretion of the proinflammatory cytokines TNF-α and IL-1β, as well as chemokines such as IL-8 and monocyte chemoattractant protein (MCP)-1. Intracellularly, TREM1 induces Ca2+ mobilization and tyrosine phosphorylation of extracellular signal-related kinase 1 (ERK1), ERK2 and phospholipase C-γ. In an animal model of LPS-induced septic shock, blockade of TREM1 signaling inhibited hyperresponsiveness and death. Thus, it has been demonstrated that TREM1 performs a critical function in immune responses involved in host defense against microbial challenges, and is suggested to be a potential therapeutic target for septic shock. |
| Conjucates | Unconjugated |
| Others Formats | Biotin |
| Antibody Types Available | 2 |
| Immunogen | Recombinant Human TREM-1 / TREM1 Protein (TMPY-01774) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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