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Anti-TROP-2 Antibody-PE (7D257)
🥰Excellent
Catalog No. TMAY-00814P
Anti-TROP-2 Antibody-PE (7D257) is a PE-conjugated Mouse antibody targeting TROP-2. Anti-TROP-2 Antibody-PE (7D257) can be used in FCM.
Anti-TROP-2 Antibody-PE (7D257)
Anti-TROP-2 Antibody-PE (7D257)
🥰Excellent
Catalog No. TMAY-00814P
Anti-TROP-2 Antibody-PE (7D257) is a PE-conjugated Mouse antibody targeting TROP-2. Anti-TROP-2 Antibody-PE (7D257) can be used in FCM.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-TROP-2 Antibody-PE (7D257) is a PE-conjugated Mouse antibody targeting TROP-2. Anti-TROP-2 Antibody-PE (7D257) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 7D257 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of anti-human TROP2 on MCF-7 cells. MCF-7 cells were detached using 1X trypsin, washed, then stained with PE Mouse anti-human TROP2. |
| Application | FCM |
| Recommended Dose | 2 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human TROP-2 / TACSTD2 (rh TROP-2 / TACSTD2; TMPY-01262; NP_002344.2; Met1-Thr274) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Research Background | TROP-2, also referred to as tumor-associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Trop-2 transduces an intracellular calcium signal, which are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate. |
| Conjucates | PE |
| Others Formats | Unconjugated/Biotin/FITC/HRP |
| Antibody Types Available | 5 |
| Immunogen | Recombinant Human TROP-2 / TACSTD2 protein (TMPY-01262) |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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