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Fludrocortisone acetate

🥰Excellent
Catalog No. T1666Cas No. 514-36-3
Alias 9α-fluorocortisol acetate, 9α-Fluorcortisol acetate, 9α-Fludrocortisone acetate

Fludrocortisone acetate (9α-Fludrocortisone acetate), a glucocorticoid-receptor agonist, binds to cytoplasmic receptors, translocates to the nucleus, and initiates transcription of glucocorticoid-responsive genes like lipocortins to inhibit phospholipase A2 (PLA2). As the acetate salt of a synthetic fluorinated corticosteroid, it exhibits anti-inflammatory and antiallergic activities. PLA2 inhibition prevents arachidonic acid release, a precursor of eicosanoids such as prostaglandins and leukotrienes, which are key mediators in the pro-inflammatory response. As a mineralocorticoid-receptor agonist, it stimulates Na+ reabsorption, water retention, and K+ and H+ secretion in the distal tubules and collecting ducts of the kidney.

Fludrocortisone acetate
Other Forms of Fludrocortisone acetate:

Fludrocortisone acetate

🥰Excellent
Purity: 98.03%
Catalog No. T1666Alias 9α-fluorocortisol acetate, 9α-Fluorcortisol acetate, 9α-Fludrocortisone acetateCas No. 514-36-3
Fludrocortisone acetate (9α-Fludrocortisone acetate), a glucocorticoid-receptor agonist, binds to cytoplasmic receptors, translocates to the nucleus, and initiates transcription of glucocorticoid-responsive genes like lipocortins to inhibit phospholipase A2 (PLA2). As the acetate salt of a synthetic fluorinated corticosteroid, it exhibits anti-inflammatory and antiallergic activities. PLA2 inhibition prevents arachidonic acid release, a precursor of eicosanoids such as prostaglandins and leukotrienes, which are key mediators in the pro-inflammatory response. As a mineralocorticoid-receptor agonist, it stimulates Na+ reabsorption, water retention, and K+ and H+ secretion in the distal tubules and collecting ducts of the kidney.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
100 mg$29In StockIn Stock
1 mL x 10 mM (in DMSO)$29In StockIn Stock
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Purity:98.03%
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Product Introduction

Bioactivity
Description
Fludrocortisone acetate (9α-Fludrocortisone acetate), a glucocorticoid-receptor agonist, binds to cytoplasmic receptors, translocates to the nucleus, and initiates transcription of glucocorticoid-responsive genes like lipocortins to inhibit phospholipase A2 (PLA2). As the acetate salt of a synthetic fluorinated corticosteroid, it exhibits anti-inflammatory and antiallergic activities. PLA2 inhibition prevents arachidonic acid release, a precursor of eicosanoids such as prostaglandins and leukotrienes, which are key mediators in the pro-inflammatory response. As a mineralocorticoid-receptor agonist, it stimulates Na+ reabsorption, water retention, and K+ and H+ secretion in the distal tubules and collecting ducts of the kidney.
Synonyms9α-fluorocortisol acetate, 9α-Fluorcortisol acetate, 9α-Fludrocortisone acetate
Chemical Properties
Molecular Weight422.49
FormulaC23H31FO6
Cas No.514-36-3
Smiles[H][C@@]12CC[C@](O)(C(=O)COC(C)=O)[C@@]1(C)CC(=O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)CC[C@]12C
Relative Density.1.3 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 45 mg/mL (106.51 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.73 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3669 mL11.8346 mL23.6692 mL118.3460 mL
5 mM0.4734 mL2.3669 mL4.7338 mL23.6692 mL
10 mM0.2367 mL1.1835 mL2.3669 mL11.8346 mL
20 mM0.1183 mL0.5917 mL1.1835 mL5.9173 mL
50 mM0.0473 mL0.2367 mL0.4734 mL2.3669 mL
100 mM0.0237 mL0.1183 mL0.2367 mL1.1835 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

Mineralocorticoid ReceptorInhibitorinhibitGlucocorticoidReceptorGlucocorticoid ReceptorFludrocortisone AcetateFludrocortisone acetateFludrocortisoneAutophagy9α-fluorocortisol Acetate9α-Fluorcortisol Acetate9α-Fluorcortisol9α-Fludrocortisone Acetate9α-Fludrocortisone9alpha-fluorocortisol Acetate9alpha-Fluorcortisol Acetate9alpha-Fludrocortisone Acetate9a-fluorocortisol Acetate9a-Fluorcortisol Acetate9a-Fludrocortisone Acetate
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