Mannoside Acetylglucosaminyltransferase 2 (MGAT2) is a single-pass type II membrane protein that contains the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain and a C-terminal catalytic domain. MGAT2 catalyzes an essential step in the conversion of oligo-mannose to complex N-glycans. Defects in MGAT2 are the cause of congenital disorder of glycosylation type 2A.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 μg | 5 days | $ 184.00 | |
50 μg | 5 days | $ 545.00 | |
500 μg | 5 days | $ 1,900.00 | |
1 mg | 5 days | $ 2,730.00 |
Description | Mannoside Acetylglucosaminyltransferase 2 (MGAT2) is a single-pass type II membrane protein that contains the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain and a C-terminal catalytic domain. MGAT2 catalyzes an essential step in the conversion of oligo-mannose to complex N-glycans. Defects in MGAT2 are the cause of congenital disorder of glycosylation type 2A. |
Species | Human |
Expression System | Human Cells |
Tag | C-6His |
Accession Number | Q10469 |
Synonyms | Alpha-1, Mannoside Acetylglucosaminyltransferase 2, 6-Mannosyl-Glycoprotein 2-β-N-Acetylglucosaminyltransferase, NT-II, GlcNAc-T II, 6-Mannosyl-Glycoprotein 2-Beta-N-Acetylglucosaminyltransferase, 2-N-acetylglucosaminyltransferase II, β-1, Beta-1, N-Glycosyl-Oligosaccharide-Glycoprotein N-Acetylglucosaminyltransferase II, α-1 |
Amino Acid | Arg30-Gln447 |
Construction | Recombinant Human Mannoside Acetylglucosaminyltransferase 2 is produced by our Mammalian expression system and the target gene encoding Arg30-Gln447 is expressed with a 6His tag at the C-terminus. |
Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
Molecular Weight | 50 KDa, reducing conditions |
Endotoxin | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0. |
Stability & Storage |
Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
Shipping |
The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below. |
Research Background | Mannoside Acetylglucosaminyltransferase 2 (MGAT2) is a single-pass type II membrane protein that contains the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain and a C-terminal catalytic domain. MGAT2 catalyzes an essential step in the conversion of oligo-mannose to complex N-glycans. Defects in MGAT2 are the cause of congenital disorder of glycosylation type 2A. |
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MGAT2 Protein, Human, Recombinant (His) Alpha-1 b-1 Mannoside Acetylglucosaminyltransferase 2 6-Mannosyl-Glycoprotein 2-β-N-Acetylglucosaminyltransferase NT-II GlcNAc-T II 6-Mannosyl-Glycoprotein 2-Beta-N-Acetylglucosaminyltransferase a-1 2-N-acetylglucosaminyltransferase II β-1 Beta-1 N-Glycosyl-Oligosaccharide-Glycoprotein N-Acetylglucosaminyltransferase II α-1 recombinant recombinant-proteins proteins protein