Shopping Cart
Remove All
Your shopping cart is currently empty
FL118
Copy Product Info
😃Good
Catalog No. T77701Cas No. 135415-73-5
Alias FL-118, FL 118, 10,11-(Methylenedioxy)-20(S)-camptothecin
FL118 is a novel survivin inhibitor that inhibits cancer stem cell-like properties.FL118 is a novel camptothecin analog with anticancer activity that inhibits epithelial-mesenchymal transition through the Wnt/β-catenin signaling pathway, thereby inhibiting migration and invasion of human breast cancer cells.
FL118
Copy Product Info😃Good
Purity: 97.14%
Catalog No. T77701Alias FL-118, FL 118, 10,11-(Methylenedioxy)-20(S)-camptothecinCas No. 135415-73-5
FL118 is a novel survivin inhibitor that inhibits cancer stem cell-like properties.FL118 is a novel camptothecin analog with anticancer activity that inhibits epithelial-mesenchymal transition through the Wnt/β-catenin signaling pathway, thereby inhibiting migration and invasion of human breast cancer cells.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $73 | In Stock | In Stock | |
| 5 mg | $156 | In Stock | In Stock | |
| 10 mg | $197 | In Stock | In Stock | |
| 25 mg | $396 | In Stock | In Stock | |
| 50 mg | $488 | In Stock | In Stock | |
| 100 mg | $787 | - | In Stock |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
Select Batch
Purity:97.14%
Appearance:Solid
Color:Yellow
Contact us for more batch information
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | FL118 is a novel survivin inhibitor that inhibits cancer stem cell-like properties.FL118 is a novel camptothecin analog with anticancer activity that inhibits epithelial-mesenchymal transition through the Wnt/β-catenin signaling pathway, thereby inhibiting migration and invasion of human breast cancer cells. |
| In vitro | FL118 (0-200 nM; 24, 48, and 72 h) suppresses cell proliferation and migration in ES-2 and SK-O-V3 cells, influencing CYGB expression and inhibiting the PI3K/AKT/mTOR pathway, altering vimentin and E-cadherin levels in ovarian cancer cells. FL118 (0-500 nM; 0-72 h) induces dephosphorylation and degradation of DDX5, regulating survivin, McL-1, XIAP, cIAP2, c-Myc, and mKras expression. FL118 (0-1 μM; 24, 48 h) exhibits cytotoxicity against A549, MDA-MB-231, and RM-1 cell lines, enhancing PARP cleavage and triggering apoptosis in A549 cells, primarily arresting them at the G2/M phase. |
| In vivo | FL118 (5 and 10 mg/kg; p.o.; once a week; 20 days; female BALB/c nude mice) dose-dependently suppressed ES-2 tumor growth by upregulating CYGB expression.[1] Additionally, FL118 (0-1.5 mg/kg; i.p.; once every other day; five times) effectively eliminated human colon and head-and-neck tumors resistant to irinotecan or topotecan.[4] FL118 (1.5 mg/kg; i.v.; once) also demonstrated favorable pharmacokinetic profiles.[4] |
| Synonyms | FL-118, FL 118, 10,11-(Methylenedioxy)-20(S)-camptothecin |
| Molecular Weight | 392.36 |
| Formula | C21H16N2O6 |
| Cas No. | 135415-73-5 |
| Smiles | C(C)[C@]1(O)C2=C(C(=O)N3C(=C2)C=4C(C3)=CC=5C(N4)=CC6=C(C5)OCO6)COC1=O |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: 2 mg/mL (5.1 mM), Sonication and heating are recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
| ||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy FL118 | purchase FL118 | FL118 cost | order FL118 | FL118 chemical structure | FL118 in vivo | FL118 in vitro | FL118 formula | FL118 molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.