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Anti-Phospho-RASA1 (Tyr460) Polyclonal Antibody
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Catalog No. TMAB-11222
Anti-Phospho-RASA1 (Tyr460) Polyclonal Antibody is a Rabbit antibody targeting Phospho-RASA1 (Tyr460). Anti-Phospho-RASA1 (Tyr460) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-Phospho-RASA1 (Tyr460) Polyclonal Antibody
Anti-Phospho-RASA1 (Tyr460) Polyclonal Antibody
😃Good
Catalog No. TMAB-11222
Anti-Phospho-RASA1 (Tyr460) Polyclonal Antibody is a Rabbit antibody targeting Phospho-RASA1 (Tyr460). Anti-Phospho-RASA1 (Tyr460) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-RASA1 (Tyr460) Polyclonal Antibody is a Rabbit antibody targeting Phospho-RASA1 (Tyr460). Anti-Phospho-RASA1 (Tyr460) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Mouse (predicted:Human,Rat,Chicken,Dog,Pig,Cow,Horse,Sheep) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. |
| Tissue Specificity | In placental villi, detected only in the trophoblast layer (cytotrophoblast and syncytiotrophoblast). Not detected in stromal, endothelial or Hofbauer cells (at protein level). |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The mammalian c-H-, c-K- and N-Ras proto-oncogenes encode ubiquitously expressed proteins (1,2). p21Ras can exist in either a physiologically quiescent GDP-binding state or a GTP-binding signal-emitting state (3). Oncogenic p21Ras proteins are trapped in the excited signal-emitting state because the mechanism normally employed to delimit their excitation period, hydrolysis of their bound GTP to GDP, is impaired as a result of specific mutations (3). Interaction of p21Ras with GTPase activating protein (GAP) can increase hydrolysis of p21Ras-bound GTP by as much as 1000-fold (4,5). The product of the neurofibromatosis type 1 gene (NF1) has also been shown to exhibit p21Ras GAP activity (6,7), and proteins that stimulate the GTPase activity of three other low molecular weight GTPases, including Rho, Rab 3A and Rap 1, have also been described (8,9). |
| Immunogen | KLH conjugated synthesised phosphopeptide: human GAP around the phosphorylation site of Tyr460 |
| Antigen Species | Human |
| Gene Name | RASA1 |
| Gene ID | |
| Protein Name | Ras GTPase-activating protein 1 |
| Uniprot ID | |
| Function | Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21. |
| Molecular Weight | Theoretical: 116 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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