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Synonyms: Krueppel-like factor 4, KLF 4, Gut-enriched krueppel-like factor, GKLF, EZF, Epithelial zinc finger protein EZF
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
| Description | Anti-KLF4 Polyclonal Antibody is a Rabbit antibody targeting KLF4. Anti-KLF4 Polyclonal Antibody can be used in FCM, ICC/IF, IF, IHC-Fr, IHC-P, WB. |
| Synonyms | Krueppel-like factor 4, KLF 4, Gut-enriched krueppel-like factor, GKLF, EZF, Epithelial zinc finger protein EZF |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | FCM=1 μg/Test; ICC/IF=1:100-500; IF=1:50-200; IHC-Fr=1:50-200; IHC-P=1:50-200; WB=1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | KLF4 is a transcription factor that works with Sp1 to activate the Laminin gamma1 chain gene. It binds the CACCC core sequence. KLF4 may be involved in the differentiation of epithelial cells and may also function in the development of the skeleton and kidney. KLF4 also has roles as both an oncogene and a tumor suppressor. |
| Immunogen | KLH conjugated synthetic peptide: human KLF4 |
| Antigen Species | Human |
| Gene Name | KLF4 |
| Gene ID | |
| Protein Name | Krueppel-like factor 4 |
| Uniprot ID | |
| Biology Area | Transcription factors,Tumor suppressors,Endothelial Cell Markers,Transcription factors,Surface molecules,Cell Cycle Inhibitors,Cell Differentiation,Krueppel like factor,Krueppel like factor,Other factors,Transcription Factors,Intracellular |
| Function | Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription. |
| Molecular Weight | Theoretical: 56 kDa. Actual: 50 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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