Measured by its ability to inhibit GM-CSF-dependent proliferation of TF‑1 human erythroleukemic cells.The ED50 for this effect is 0.5-2 μg/ml. (QC verified)

GM-CSFR alpha Protein, Human, Recombinant (His) V2 is expressed in HEK293 Cells. The accession number is P15509.

Human

HEK293 Cells

SMDP4,GMR,GM-CSF-R-α,GM-CSF-R-alpha,GMCSFR,GM-CSF Receptor α Protein,CSF2RY,CSF2RX,CSF2RAY,CSF2RAX,CSF2R,colony stimulating factor 2 receptor, α, low-affinity (granulocyte-macrophage),colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage),CDw116,CD116

Glu23-Gly320

> 95% as determined by SDS-PAGE

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Granulocyte-Macrophage Colony-Stimulating Factor Receptor Subunit α (CSF2RA) is a single-pass type I membrane protein which belongs to the type I cytokine receptor family of Type 5 subfamily. The CSF2RA gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes with some of the isoforms being membrane-bound and others being soluble. CSF2RA is a low affinity receptor for granulocyte-macrophage colony-stimulating factor. CSF2RA transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. Defects in CSF2RA are the cause of pulmonary surfactant metabolism dysfunction type 4 (SMDP4).