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AZD-7648

Name: AZD-7648
Brand: TargetMol
SKU: T7122
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7122Cas No. 2230820-11-6

AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.

AZD-7648

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Purity: 99.85%

Catalog No. T7122Cas No. 2230820-11-6

AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$34	In Stock	In Stock
5 mg	$80	In Stock	In Stock
10 mg	$122	In Stock	In Stock
25 mg	$197	In Stock	In Stock
50 mg	$328	In Stock	In Stock
100 mg	$497	In Stock	In Stock
200 mg	$723	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$89	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.85%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

AZD-7648 AI Summary

AZD-7648 exhibits potent bioactivity as a DNA-PK inhibitor, with an IC50 of 0.6-0.631 nM in TR-FRET assays involving the DNA-PK catalytic subunit in human HeLa cells. It also effectively inhibits DNA-PK in human A549 cells with an IC50 range of 91.0-100.0 nM, showing a selective preference over other kinases such as PI3K isoforms, ATM, ATR, and mTOR. The compound has favorable oral bioavailability in Han Wistar rats and Beagle dogs and demonstrates adequate solubility in simulated intestinal and gastric fluids. Additionally, it shows moderate to high plasma protein binding, and metabolic stability in human liver microsomes with an intrinsic clearance of 6.4 mL.min-1.g-1. AZD-7648 induces apoptosis in human HCT-116 cells, disrupts mitochondrial function, causes cell cycle arrest, and shows synergistic antiproliferative and antitumor activity in animal models. While demonstrating minimal effects on hERG expressed in CHO cells, the compound exhibits complex impacts on the thermal stability of various protein domains. Overall, AZD-7648's bioactivity and pharmacokinetic profiles suggest significant potential for further evaluation as a targeted DNA-PK inhibitor..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.
Targets&IC50	ATM:17.93 μM, PI3Kγ:1.37 μM, DNA-PK:0.63 nM

Chemical Properties

Molecular Weight	380.4
Formula	C₁₈H₂₀N₈O₂
Cas No.	2230820-11-6
Smiles	Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n(C3CCOCC3)c2n1
Relative Density.	1.60 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 9.52 mg/mL (25.03 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6288 mL	13.1441 mL	26.2881 mL	131.4406 mL
5 mM	0.5258 mL	2.6288 mL	5.2576 mL	26.2881 mL
10 mM	0.2629 mL	1.3144 mL	2.6288 mL	13.1441 mL
20 mM	0.1314 mL	0.6572 mL	1.3144 mL	6.5720 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc