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3-Isomangostin

Name: 3-Isomangostin
Brand: TargetMol
SKU: T2S1635
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2S1635Cas No. 19275-46-8

3-Isomangostin is an acetylcholinesterase selective inhibitor and a potent human aldose reductase inhibitor with an IC50 of 3.48 uM. 3-Isomangostin has free radical scavenging activity and inhibits MutT homolog 1 (MTH1) with an IC50 of 52 nM. It shows antiplasmodial activity with an IC50 values in the range of 4.71-11.40 uM. 3-Isomangostin can be used to develop anticancer agents as well.

3-Isomangostin

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Purity: 99.9%

Catalog No. T2S1635Cas No. 19275-46-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	In Stock	In Stock
5 mg	$106	In Stock	In Stock
10 mg	$179	In Stock	In Stock
25 mg	$297	In Stock	In Stock
50 mg	$453	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$128	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.9%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	3-Isomangostin is an acetylcholinesterase selective inhibitor and a potent human aldose reductase inhibitor with an IC50 of 3.48 uM. 3-Isomangostin has free radical scavenging activity and inhibits MutT homolog 1 (MTH1) with an IC50 of 52 nM. It shows antiplasmodial activity with an IC50 values in the range of 4.71-11.40 uM. 3-Isomangostin can be used to develop anticancer agents as well.
Targets&IC50	MTH1:52 nM
In vitro	Species of Garcinia have been used to combat malaria in traditional African and Asian medicines, including Ayurveda. In the current study, we have identified antiplasmodial benzophenone and xanthone compounds from edible Garcinia species by testing for in vitro inhibitory activity against Plasmodium falciparum. Whole fruits of Garcinia xanthochymus, G. mangostana, G. spicata, and G. livingstonei were extracted and tested for antiplasmodial activity. Garcinia xanthochymus was subjected to bioactivity-guided fractionation to identify active partitions. Purified benzophenones (1-9) and xanthones (10-18) were then screened in the plasmodial lactate dehydrogenase assay and tested for cytotoxicity against mammalian (Vero) cells. The benzophenones guttiferone E (4), isoxanthochymol (5), and guttiferone H (6), isolated from G. xanthochymus, and the xanthones α-mangostin (15), β-mangostin (16), and 3-Isomangostin (17), known from G. mangostana, showed antiplasmodial activity with an IC50 values in the range of 4.71-11.40 μM. Artemisinin and chloroquine were used as positive controls and exhibited an IC50 values in the range of 0.01-0.24 μM.

Chemical Properties

Molecular Weight	410.46
Formula	C₂₄H₂₆O₆
Cas No.	19275-46-8
Smiles	COc1c(O)cc2oc3cc4OC(C)(C)CCc4c(O)c3c(=O)c2c1CC=C(C)C
Relative Density.	1.257 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 40 mg/mL (97.45 mM), Sonication is recommended.

DMSO: 40 mg/mL (97.45 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4363 mL	12.1815 mL	24.3629 mL	121.8145 mL
5 mM	0.4873 mL	2.4363 mL	4.8726 mL	24.3629 mL
10 mM	0.2436 mL	1.2181 mL	2.4363 mL	12.1815 mL
20 mM	0.1218 mL	0.6091 mL	1.2181 mL	6.0907 mL
50 mM	0.0487 mL	0.2436 mL	0.4873 mL	2.4363 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc