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Anti-PRMT1 Antibody (6O126) is a Rabbit antibody targeting PRMT1. Anti-PRMT1 Antibody (6O126) can be used in WB,ICC/IF,IHC,ChIP.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μL | $298 | 7-10 days | |
100 μL | $497 | 7-10 days |
Description | Anti-PRMT1 Antibody (6O126) is a Rabbit antibody targeting PRMT1. Anti-PRMT1 Antibody (6O126) can be used in WB,ICC/IF,IHC,ChIP. |
Synonyms | S. cerevisiae like 2, R1B4, Protein arginine N-methyltransferase 1, Protein arginine N methyltransferase1, Protein arginine N methyltransferase 1, Protein arginine methyltransferase 1, PRMT1, PRMT 1, Mrmt1, Mrmt 1, IR1B4, IR1B 4, IR1 B4, Interferon receptor 1-bound protein 4, Interferon receptor 1bound protein 4, Interferon receptor 1 bound protein4, Interferon receptor 1 bound protein 4, Human mRNA for suppressor for yeast mutant complete cds, Human mRNA for suppressor for yeast mutant, HRMT1L2, HRMT1L 2, HRMT1 L2, HMT2, HMT1 hnRNP methyltransferase like 2 (S. cerevisiae), HMT1 hnRNP methyltransferase like 2, HMT1 hnRNP methyltransferase, HMT1 (hnRNP methyltransferase S. cerevisiae) like 2, HMT 2, Histone-arginine N-methyltransferase PRMT1, Heterogeneous nuclear ribonucleoproteins methyltransferase like2, Heterogeneous nuclear ribonucleoproteins methyltransferase like 2, Heterogeneous nuclear ribonucleoprotein methyltransferase 1 like 2, HCP1, HCP 1, ANM1_HUMAN, ANM1, ANM 1 |
Ig Type | IgG |
Reactivity | Human,Mouse,Rat |
Verified Activity | 1. Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using anti-PRMT1 antibody. Counter stained with hematoxylin. 2. Immunohistochemical analysis of paraffin-embedded mouse liver tissue using anti-PRMT1 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-PRMT1 antibody. Counter stained with hematoxylin. 4. ICC staining PRMT1 in D3 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 5. ICC staining PRMT1 in NIH-3T3 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 6. ICC staining PRMT1 in Hela cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 7. ICC staining PRMT1 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 8. ICC staining PRMT1 in SW480 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. |
Application | |
Recommended Dose | WB: 1:500-1000; IHC: 1:50-200; ICC/IF: 1:100-500 |
Antibody Type | Monoclonal |
Host Species | Rabbit |
Construction | Recombinant Antibody |
Purification | ProA affinity purified |
Appearance | Liquid |
Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
Research Background | A class of proteins termed type 1 protein arginine N-methyltransferase (PRMT) enzymes contribute to posttranslational modification of RNA-binding proteins, but differ in substrate specificities, oligomerization properties and subcellular localization. PRMT1, the predominant form in mammalian cells, is located in the nucleus, while PRMT3 is present in the cytoplasm. At the carboxy-terminus, interleukin enhancer-binding factor 3 (ILF3) binds PRMT1, thereby regulating PRMT1 activitiy. Alternative mRNA splicing of the PRMT gene results in three isoforms of PRMT1 that differ in their amino-terminus regions. All three splice variants of PRMT1 are enzymatically active. PRMT3 recognizes and binds to RNA-associated substrates with a zinc-finger domain in its amino-terminus. The zinc-liganded form of this domain is required for the enzyme to recognize RNA-associated substrates. |
Conjucates | Unconjugated |
Immunogen | Recombinant Protein |
Uniprot ID |
Molecular Weight | Theoretical: 42 kDa. |
Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
Transport | Shipping with blue ice. |
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