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Impromidine hydrochloride

Catalog No. T68921 CAS 65573-02-6

Impromidine hydrochloride is a very potent and specific histamine H2 receptor agonist for conducting cardiovascular studies.

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Impromidine hydrochloride Chemical Structure

Impromidine hydrochloride, CAS 65573-02-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 258.00
5 mg	In stock	$ 642.00
10 mg	In stock	$ 913.00
25 mg	In stock	$ 1,370.00
50 mg	In stock	$ 1,850.00
100 mg	In stock	$ 2,500.00
500 mg	In stock	$ 4,900.00

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Purity: 99.50%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Impromidine hydrochloride is a very potent and specific histamine H2 receptor agonist for conducting cardiovascular studies.
In vitro	Impromidine hydrochloride (1 X 10(-4) M; human isolated left ventricular) inhibited maximal responses to histamine to a level equal to the maximal Impromidine hydrochloride response; however, Impromidine hydrochloride did not inhibit responses to isoprenaline. Positive inotropic activity and inhibition of maximal responses to histamine occurred over a similar Impromidine hydrochloride concentration range. Impromidine hydrochloride displaced histamine concentration-response curves to the right, whereas mepyramine had no effect on responses to histamine. It is concluded that Impromidine hydrochloride has positive inotropic activity on the human ventricle, that the response is mediated via histamine H2-receptors, and that Impromidine hydrochloride is a partial agonist compared with histamine.[2]
In vivo	Impromidine hydrochloride (0.46 to 46 nmol/kg/h; dog; 45-min steps) produced the same maximum stimulation of gastric HCI output, increase of HR, and fall in systolic blood pressure as histamine. Impromidine hydrochloride was 38 times more potent than histamine in the stimulation of acid (ED50 3.8 nmol/kg/h) and 30 times more potent in raising HR (ED50 5.6 vs. 172 nmol/kg.hr). The effects of Impromidine hydrochloride on pepsin secretion were qualitatively and quantitatively similar to those of histamine and other H-2 agonists with weak stimulation at low doses and progressive inhibition with increasing doses of Impromidine hydrochloride. Coupling the results with the known high specificity of Impromidine hydrochloride, gastric acid secretion, chronotropic, and hypotension all seem to be purely H-2-mediated effects of histamine in the intact conscious dog.[1]

Molecular Weight	430.83
Formula	C14H26Cl3N7S
CAS No.	65573-02-6

Storage

store under nitrogen

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27.5 mg/mL (63.83 mM), Sonication is recommended.

References and Literature

1. Molina E, et al. Use of impromidine to define specific histamine H-2 effects on gastric secretion, heart rate and blood pressure in conscious dogs. J Pharmacol Exp Ther. 1980;214(3):483-487. 2. English TA, et al. Impromidine is a partial histamine H2-receptor agonist on human ventricular myocardium. Br J Pharmacol. 1986;89(2):335-340. 3. Aksulu HE, et al. A comparative study with impromidine (SKF 92676), a potent agonist for histamine H2-receptors. Agents Actions. 1979;9(5-6):461-466.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Membrane Protein-targeted Compound Library Bioactive Compounds Library Max Bioactive Compound Library Neuronal Signaling Compound Library

Related Products

Related compounds with same targets

Famotidine JTE-952 Lodoxamide tromethamine Cyproheptadine hydrochloride sesquihydrate Levocarnitine propionate hydrochloride Chlorcyclizine Fexofenadine hydrochloride H3R-IN-1 Hydrochloride

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Keywords

Impromidine hydrochloride 65573-02-6 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor Impromidine HCl Impromidine trihydrochloride Impromidine Hydrochloride inhibitor inhibit

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