Nucleoside phosphorylase/PNP Protein, Human, Recombinant (His)

Catalog No. TMPY-02279 Copy Product Info

Purine nucleoside phosphorylase (PNP) is a purine-metabolizing enzyme that catalyzes the reversible phosphorolysis of 6-oxypurine (deoxy)nucleosides to their respective bases and (deoxy)ribose-1-phosphate. It is a key enzyme in the purine salvage pathway of mammalian cells. Purine nucleoside phosphorylase is a transferase that catalyzes the addition of phosphate and removal of a purine base from guanosine and similar nucleosides.PNP defects result in metabolic abnormalities and fatal T cell immunodeficiency. Purine nucleoside phosphorylase (PNP) is a target for leukemia, gout, and autoimmune disorders.

Nucleoside phosphorylase/PNP Protein, Human, Recombinant (His)

Catalog No. TMPY-02279

Copy Product Info

Nucleoside phosphorylase/PNP Protein, Human, Recombinant (His)

Pack Size	Price	USA Stock	Global Stock
5 μg	$75	7-10 days	7-10 days
10 μg	$118	7-10 days	7-10 days
20 μg	$196	7-10 days	7-10 days
50 μg	$386	7-10 days	7-10 days

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For In stock only · Estimated delivery:USA Stock (1-2 days) Global Stock (5-7 days)

For research use only—not for human use. No sales to individuals. Use as intended only.

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Biological Activity	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	Purine nucleoside phosphorylase (PNP) is a purine-metabolizing enzyme that catalyzes the reversible phosphorolysis of 6-oxypurine (deoxy)nucleosides to their respective bases and (deoxy)ribose-1-phosphate. It is a key enzyme in the purine salvage pathway of mammalian cells. Purine nucleoside phosphorylase is a transferase that catalyzes the addition of phosphate and removal of a purine base from guanosine and similar nucleosides.PNP defects result in metabolic abnormalities and fatal T cell immunodeficiency. Purine nucleoside phosphorylase (PNP) is a target for leukemia, gout, and autoimmune disorders.
Species	Human
Expression System	E. coli
Tag	C-His
Accession Number	P00491
Synonyms	purine nucleoside phosphorylase,PUNP,PRO1837,NP
Construction	A DNA sequence encoding the human PNP (P00491) (Met 1-Ser 289) was fused with a polyhistide tag at the C-terminus. Predicted N terminal: Met
Protein Purity	> 97 % as determined by SDS-PAGE
Molecular Weight	33.5 kDa (predicted); 33.5 kDa (reducing conditions)
Endotoxin	Please contact us for more information.
Formulation	Supplied as sterile PBS, 25% glycerol, pH 7.5.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	Proteins are shipped with blue ice.
Research Background	Purine nucleoside phosphorylase (PNP) is a purine-metabolizing enzyme that catalyzes the reversible phosphorolysis of 6-oxypurine (deoxy)nucleosides to their respective bases and (deoxy)ribose-1-phosphate. It is a key enzyme in the purine salvage pathway of mammalian cells. Purine nucleoside phosphorylase is a transferase that catalyzes the addition of phosphate and removal of a purine base from guanosine and similar nucleosides.PNP defects result in metabolic abnormalities and fatal T cell immunodeficiency. Purine nucleoside phosphorylase (PNP) is a target for leukemia, gout, and autoimmune disorders.