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JMJD7-IN-1

🥰Excellent
Catalog No. T9094Cas No. 311316-96-8
Alias Benzoic acid, 2,4-dichloro-, 5-nitro-8-quinolinyl ester

JMJD7-IN-1 (Benzoic acid, 2,4-dichloro-, 5-nitro-8-quinolinyl ester) is a potent JMJD7 inhibitor, with an IC50 of 6.62 μM. JMJD7-IN-1 shows good inhibitory activity against cells expressing a high level of JMJD7.

JMJD7-IN-1

JMJD7-IN-1

🥰Excellent
Purity: 99.66%
Catalog No. T9094Alias Benzoic acid, 2,4-dichloro-, 5-nitro-8-quinolinyl esterCas No. 311316-96-8
JMJD7-IN-1 (Benzoic acid, 2,4-dichloro-, 5-nitro-8-quinolinyl ester) is a potent JMJD7 inhibitor, with an IC50 of 6.62 μM. JMJD7-IN-1 shows good inhibitory activity against cells expressing a high level of JMJD7.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$40In StockIn Stock
10 mg$64In StockIn Stock
25 mg$139In StockIn Stock
50 mg$222In StockIn Stock
100 mg$363In StockIn Stock
1 mL x 10 mM (in DMSO)$44In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.66%
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Product Introduction

Bioactivity
Description
JMJD7-IN-1 (Benzoic acid, 2,4-dichloro-, 5-nitro-8-quinolinyl ester) is a potent JMJD7 inhibitor, with an IC50 of 6.62 μM. JMJD7-IN-1 shows good inhibitory activity against cells expressing a high level of JMJD7.
Targets&IC50
JMJD7:6.62 μM
In vitro
JMJD7-IN-1 efficiently binds to JMJD7, with an IC50 of 3.80 μM.?JMJD7-IN-1 (72 h) inhibits the growth of T-47d, SK-BR-3, Jurkat and Hela cells, with IC50s of 9.40 μM, 13.26 μM, 15.03 μM and 16.14 μM, respectively. JMJD7-IN-1 (0.1-1000 μM) dose-dependently inhibits the activity of JMJD7, with an IC50 of 6.62 μM.
SynonymsBenzoic acid, 2,4-dichloro-, 5-nitro-8-quinolinyl ester
Chemical Properties
Molecular Weight363.15
FormulaC16H8Cl2N2O4
Cas No.311316-96-8
Smiles[O-][N+](=O)c1ccc(OC(=O)c2ccc(Cl)cc2Cl)c2ncccc12
Relative Density.1.539 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 3.64 mg/mL (10.02 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7537 mL13.7684 mL27.5368 mL137.6842 mL
5 mM0.5507 mL2.7537 mL5.5074 mL27.5368 mL
10 mM0.2754 mL1.3768 mL2.7537 mL13.7684 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

JMJD7-IN-1JMJD-7-IN-1JMJD7IN1JMJD7 IN 1JMJD7InhibitorinhibitHistoneDemethylaseHistone Demethylasecancer
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