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Pasiniazid

Name: Pasiniazid
Brand: TargetMol
SKU: T0441
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0441Cas No. 2066-89-9

Alias Pasiniazide, Paraniazide, Isonicotinic acid hydrazide p-aminosalicylate

Pasiniazid (Paraniazide) is an anti-TB and anti-leprosy drug.

Pasiniazid

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Purity: 99.77%

Catalog No. T0441Alias Pasiniazide, Paraniazide, Isonicotinic acid hydrazide p-aminosalicylateCas No. 2066-89-9

Pasiniazid (Paraniazide) is an anti-TB and anti-leprosy drug.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$30	In Stock	In Stock
500 mg	$42	-	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.77%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Pasiniazid AI Summary

Pasiniazid displays bioactivity as an inhibitor in various assays. It inhibits Human Jumonji Domain Containing 2E (JMJD2E) with a potency of 39810.7 nM, Tyrosyl-DNA Phosphodiesterase (TDP1) with a potency of 5623.4 nM, and Tau Fibril Formation as indicated by Thioflavin T Binding with a potency of 14125.4 nM. Additionally, it inhibits Retinoid-related Orphan Receptor Gamma (RORγ) transcriptional activity with a potency of 11220.2 nM and ALDH1A1 with a potency of 25118.9 nM. It is also noted for inhibiting RORγ transcriptional activity in a VP16 counterscreen with a potency of 35481.3 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Pasiniazid (Paraniazide) is an anti-TB and anti-leprosy drug.
Synonyms	Pasiniazide, Paraniazide, Isonicotinic acid hydrazide p-aminosalicylate

Chemical Properties

Molecular Weight	290.28
Formula	C₁₃H₁₄N₄O₄
Cas No.	2066-89-9
Smiles	NNC(=O)C1=CC=NC=C1.NC1=CC(O)=C(C=C1)C(O)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (172.25 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4449 mL	17.2247 mL	34.4495 mL	172.2475 mL
5 mM	0.6890 mL	3.4449 mL	6.8899 mL	34.4495 mL
10 mM	0.3445 mL	1.7225 mL	3.4449 mL	17.2247 mL
20 mM	0.1722 mL	0.8612 mL	1.7225 mL	8.6124 mL
50 mM	0.0689 mL	0.3445 mL	0.6890 mL	3.4449 mL
100 mM	0.0344 mL	0.1722 mL	0.3445 mL	1.7225 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc