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HPG1860
(Synonyms: HPG-1860, HPG 1860) Copy Product Info
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Synonyms: HPG-1860, HPG 1860
Catalog No. T201349 Copy Product Info
Purity: 99.02%
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HPG1860 is a farnesol X receptor (FXR) agonist that effectively activates FXR-mediated transcriptional activity, with an EC50 value of 18 nM. In vivo studies have shown that HPG1860, administered at doses of 1, 3 or 10 mg/kg daily, reduces serum alanine aminotransferase (ALT) and total cholesterol levels in mouse models of non-alcoholic steatohepatitis (NASH) induced by a high-fat diet and carbon tetrachloride (CCl₄). HPG1860 also reduces levels of liver inflammation, lipid accumulation and fibrosis. Consequently, HPG1860 is suitable for research into metabolic diseases, liver fibrosis, bile acid signalling and FXR-mediated transcriptional regulation.
Cas No. 2226133-29-3
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $89 | - | In Stock | |
| 5 mg | $355 | - | In Stock | |
| 10 mg | $569 | - | In Stock | |
| 25 mg | $1,060 | - | In Stock | |
| 50 mg | $1,490 | - | In Stock | |
| 100 mg | $1,970 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $448 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
Batch Information
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Purity:99.02%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | HPG1860 is a farnesol X receptor (FXR) agonist that effectively activates FXR-mediated transcriptional activity, with an EC50 value of 18 nM. In vivo studies have shown that HPG1860, administered at doses of 1, 3 or 10 mg/kg daily, reduces serum alanine aminotransferase (ALT) and total cholesterol levels in mouse models of non-alcoholic steatohepatitis (NASH) induced by a high-fat diet and carbon tetrachloride (CCl₄). HPG1860 also reduces levels of liver inflammation, lipid accumulation and fibrosis. Consequently, HPG1860 is suitable for research into metabolic diseases, liver fibrosis, bile acid signalling and FXR-mediated transcriptional regulation. |
| Targets & IC50 | FXR:0.018μM(EC50) |
| In vitro | HPG1860 (compound 23) is a potent full FXR agonist with EC50=0.018 μM detected by Luciferase Assay[1].
HPG1860 exhibits good stability in human, rat, dog, and monkey liver microsomes, with t1/2 of 447.18, 115.79, 237.17, and 154.38 min, respectively. [1] |
| In vivo | HPG1860 (compound 23) (3mg/kg; p.o.) significantly improve the expression of FXR target genes (SHP, BSEP, and FGF15) in the liver and ileum. [1]
HPG1860 (compound 23) (1-10 mg/kg, p.o., once a day, 27 days) demonstrats potent antifibrosis and anti-non-alcoholic steatohepatitis activity in a mouse model of non-alcoholic steatohepatitis induced by a high-fat diet and carbon tetrachloride. [1] |
| Synonyms | HPG-1860, HPG 1860 |
| Molecular Weight | 573.49 |
| Formula | C27H26Cl2N4O4S |
| Cas No. | 2226133-29-3 |
| Smiles | C(C=1C(=NOC1C2CC2)C3=C(Cl)C=CC=C3Cl)N4C[C@@H](C)N(CC4)C5=NC=6C(S5)=CC(C(O)=O)=CC6OC |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 57 mg/mL (99.39 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: HPG1860 chemical structure | HPG1860 in vivo | HPG1860 in vitro | HPG1860 formula | HPG1860 molecular weight
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