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AZD5582

Name: AZD5582
Brand: TargetMol
SKU: T14378
Price: 49 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14378Cas No. 1258392-53-8

AZD5582 is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. It induces apoptosis.

AZD5582

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Purity: 98.75%

Catalog No. T14378Cas No. 1258392-53-8

AZD5582 is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. It induces apoptosis.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$49	In Stock	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.75%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	AZD5582 is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. It induces apoptosis.
Targets&IC50	XIAP:15 nM (IC50), CIAP2:21 nM (IC50), CIAP1:15 nM (IC50)
In vitro	AZD5582 (20 nM; 48 hours) inhibited cell viability by cooperating with IFNγ or viral double-stranded RNA (dsRNA) in H1975 NSCLC cells[2]. In HCC827 NSCLC cells, AZD5582 (20 nM; 48 hours) induced apoptosis by activating cell death and caspase-3/-8 through co-treatment with IFNγ[2]. Additionally, AZD5582 (20 nM; 17 or 25 hours) down-regulated cIAP-1, activated RIPK1 (an upstream regulator of caspase-8), and initiated both extrinsic (caspase-8) and intrinsic (caspase-9) apoptosis pathways, leading to the cleavage of caspase-3 and caspase-7[2].
In vivo	AZD5582 (intravenous injection; 0.1-3.0 mg/kg; once a week; 2 weeks) induces cIAP1 degradation and caspase 3 cleavage in tumor cells, leading to significant tumor resolution after two weeks. A medium dose (0.5 mg/kg) of AZD5582 degrades cIAP1 but requires additional time to achieve apoptosis-inducing effects[1].

Chemical Properties

Molecular Weight	1015.29
Formula	C₅₈H₇₈N₈O₈
Cas No.	1258392-53-8
Smiles	OC(=O)C(F)(F)F.CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)N[C@@H]1[C@@H](Cc2ccccc12)OCC#CC#CCO[C@@H]1Cc2ccccc2[C@@H]1NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C1CCCCC1
Relative Density.	1.26 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 66.25 mg/mL (65.25 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (1.97 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9849 mL	4.9247 mL	9.8494 mL	49.2470 mL
5 mM	0.1970 mL	0.9849 mL	1.9699 mL	9.8494 mL
10 mM	0.0985 mL	0.4925 mL	0.9849 mL	4.9247 mL
20 mM	0.0492 mL	0.2462 mL	0.4925 mL	2.4624 mL
50 mM	0.0197 mL	0.0985 mL	0.1970 mL	0.9849 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc