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AKV-9

😃Good
Catalog No. T203125Cas No. 1307262-15-2
Alias AKV9, AKV 9

AKV-9 is a mutant Cu/Zn superoxide dismutase (SOD1) inhibitor that effectively suppresses SOD1-induced protein aggregation and demonstrates significant protective effects against SOD1-induced cytotoxicity in PC-12 cells, with an EC50 of 0.3 μM. AKV-9 also ameliorates amyotrophic lateral sclerosis (ALS)-related phenotypes and significantly prolongs survival in mouse models, making it suitable for ALS pathogenesis and targeted therapy research.

AKV-9

AKV-9

😃Good
Purity: 99.85%
Catalog No. T203125Alias AKV9, AKV 9Cas No. 1307262-15-2
AKV-9 is a mutant Cu/Zn superoxide dismutase (SOD1) inhibitor that effectively suppresses SOD1-induced protein aggregation and demonstrates significant protective effects against SOD1-induced cytotoxicity in PC-12 cells, with an EC50 of 0.3 μM. AKV-9 also ameliorates amyotrophic lateral sclerosis (ALS)-related phenotypes and significantly prolongs survival in mouse models, making it suitable for ALS pathogenesis and targeted therapy research.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$195-In Stock
5 mg$483-In Stock
10 mg$691-In Stock
25 mg$1,080-In Stock
50 mg$1,490-In Stock
100 mg$1,960-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.85%
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Product Introduction

Bioactivity
Description
AKV-9 is a mutant Cu/Zn superoxide dismutase (SOD1) inhibitor that effectively suppresses SOD1-induced protein aggregation and demonstrates significant protective effects against SOD1-induced cytotoxicity in PC-12 cells, with an EC50 of 0.3 μM. AKV-9 also ameliorates amyotrophic lateral sclerosis (ALS)-related phenotypes and significantly prolongs survival in mouse models, making it suitable for ALS pathogenesis and targeted therapy research.
In vitro
In in vitro models utilizing Upper Motor Neurons (UMNs) derived from hSOD1G93A mice, AKV-9 effectively reduced the levels of misfolded SOD1 and TDP-43 proteins. This treatment restored the structural integrity of mitochondria and the endoplasmic reticulum (ER), leading to improved axon length and branching [3].
In vivo
In in vivo animal models, AKV-9 demonstrated the ability to cross the blood-brain barrier. In hSOD1G93A ALS mice, daily administration of AKV-9 significantly improved motor performance, as evidenced by enhanced grip strength in the hanging wire test [3].
SynonymsAKV9, AKV 9
Chemical Properties
Molecular Weight368.27
FormulaC16H14F6O3
Cas No.1307262-15-2
SmilesC(F)(F)(F)C1=CC(C(F)(F)F)=CC(O[C@@H](C)C2CC(=O)CC(=O)C2)=C1
ColorWhite
AppearanceSolid
Storage & Solubility Information
StorageIn solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
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2 Enter the in vivo formulation:
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