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MRTX0902

Catalog No. T9755 CAS 2654743-22-1

MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 nM and a Ki of 2 nM.

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MRTX0902, CAS 2654743-22-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 412.00
5 mg	In stock	$ 857.00
10 mg	In stock	$ 1,355.00
25 mg	In stock	$ 2,795.00
50 mg	In stock	$ 3,654.00

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Purity: 98.37%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 nM and a Ki of 2 nM.
In vitro	In the MIA PaCa-2 xenograft model of mice, MRTX0902 (25 and 50 mg/kg; p.o.) shows anti-tumor effects and reduces tumor growth by 41% and 53%, respectively[1].

Molecular Weight	388.475
Formula	C22H24N6O
CAS No.	2654743-22-1

Storage

store at low temperture

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mg/mL (25.7 mM), ultrasonic and warming and heat to 60°C

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Ketcham JM, et al. Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein-Protein Interaction. J Med Chem. 2022 Jul 28;65(14):9678-9690.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Colorectal Cancer Compound Library Anti-Prostate Cancer Compound Library

Related Products

Related compounds with same targets

Griffipavixanthone Pseudoginsenoside Rh2 I-37 GSK1904529A MCP110 Raf inhibitor 1 6H05 LY2452473

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MRTX0902 2654743-22-1 MAPK Raf Inhibitor inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.