Shopping Cart

Your shopping cart is currently empty

NGP555

Name: NGP555
Brand: TargetMol
SKU: T16294
Price: 71 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T16294Cas No. 1304630-27-0

NGP555 is a modulator of γ-secretase.

NGP555

🥰Excellent

Purity: 99.86%

Catalog No. T16294Cas No. 1304630-27-0

NGP555 is a modulator of γ-secretase.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$71	In Stock	In Stock
2 mg	$101	In Stock	In Stock
5 mg	$197	In Stock	In Stock
10 mg	$308	In Stock	In Stock
25 mg	$519	In Stock	In Stock
50 mg	$753	In Stock	In Stock
100 mg	$1,060	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$215	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.86%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	NGP555 is a modulator of γ-secretase.
In vitro	NGP555 effectively lowers Aβ42 in cell cultures (9 nM) and increasing shorter forms of Aβ at the same time .
In vivo	NGP555 also shows good oral bioavailability and is brain-penetrant with a brain: plasma ratio of ~0.93 in mice. NGP555-treated Tg mice show significant protection from a decline in performance with >65% less decline (P<0.005) when comparing the differential of Tg to non-Tg vehicle-treated mice. NGP555 obviously lowers Aβ42 in the cerebrospinal fluid (CSF) at time points from 8 to10 hours post-dose. When combining the reduction of Aβ42 with an increase in Aβ38, NGP555 is effective at raising CSF Aβ38/42 ratio at 1.87 mg/kg and above .

Chemical Properties

Molecular Weight	406.52
Formula	C₂₃H₂₃FN₄S
Cas No.	1304630-27-0
Smiles	CCc1cc(Nc2nc(cs2)-c2ccc(c(F)c2)-n2cnc(C)c2)c(C)cc1C
Relative Density.	1.24 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (61.5 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (4.92 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4599 mL	12.2995 mL	24.5990 mL	122.9952 mL
5 mM	0.4920 mL	2.4599 mL	4.9198 mL	24.5990 mL
10 mM	0.2460 mL	1.2300 mL	2.4599 mL	12.2995 mL
20 mM	0.1230 mL	0.6150 mL	1.2300 mL	6.1498 mL
50 mM	0.0492 mL	0.2460 mL	0.4920 mL	2.4599 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc