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Anti-TULP3 Polyclonal Antibody
😃Good
Catalog No. TMAB-13894
Anti-TULP3 Polyclonal Antibody is a Rabbit antibody targeting TULP3. Anti-TULP3 Polyclonal Antibody can be used in WB.
Anti-TULP3 Polyclonal Antibody
Anti-TULP3 Polyclonal Antibody
😃Good
Catalog No. TMAB-13894
Anti-TULP3 Polyclonal Antibody is a Rabbit antibody targeting TULP3. Anti-TULP3 Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $371 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-TULP3 Polyclonal Antibody is a Rabbit antibody targeting TULP3. Anti-TULP3 Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Rat,Chicken,Dog,Horse) |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Cell membrane. Cell projection, cilium (By similarity). Cytoplasm (By similarity). Secreted (By similarity). Note=Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity). Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha. |
| Tissue Specificity | Expressed at high levels in testis, ovaries, thyroid, and spinal chord. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Mutations in the mouse Tub gene gradually lead to obesity, strongly resembling the late-onset obesity observed in the human population. In addition to excessive deposition of adipose tissue, mice with the Tub phenotype also suffer retinal degeneration and neurosensory hearing loss. A human homolog of the Tub gene has been identified, as have three related proteins, called Tubby-like protein 1 (TULP1), TULP2 and TULP3. When compared to TULP1 and TULP2, TULP3 has a wider tissue expression and is phylogenetically more similar to Tub than either TULP1 or TULP2. TULP1, expressed specifically in the retina, maps to the chromosomal region known to be involved in retinitis pigmentosa, while TULP2 maps within the minimal interval for the rod-cone dystrophy. TULP3 maps to human chromosome 12p13, and shares 69% homology to mouse TULP3. Human RNA from testis, ovary, thyroid and spinal cord contain highly detectable levels of TULP3 transcripts. In the retina, TULP3 is expressed specifically in the inner nuclear layer and ganglion cell layer. TULP1, TULP2 and TULP3 may comprise a unique family of bipartite transcription factors. |
| Immunogen | KLH conjugated synthetic peptide: human TULP3 |
| Antigen Species | Human |
| Gene Name | TULP3 |
| Gene ID | |
| Protein Name | Tubby-related protein 3 |
| Uniprot ID | |
| Function | Negatively regulates SHH signal transduction (By similarity). Probably functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to phosphorylated inositide lipids. |
| Molecular Weight | Theoretical: 50 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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