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Skp2 inhibitor 1

Name: Skp2 inhibitor 1
Brand: TargetMol
SKU: T87407
Price: 483 USD
Availability: InStock
Rating: 5 (10 reviews)

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Synonyms:

Catalog No. T87407 Copy Product Info

Purity: 99.18%

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Skp2 inhibitor 1 is a Skp2-Cks1 interaction inhibitor (IC50: 2.8μM) with antitumor activity and can be used to study cancer.

Cas No. 2760612-63-1

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Pack Size	Price	USA Stock	Global Stock
1 mg	$195	In Stock	In Stock
5 mg	$483	In Stock	In Stock
10 mg	Inquiry	-	In Stock
25 mg	Inquiry	-	In Stock
50 mg	Inquiry	Inquiry	Inquiry
100 mg	Inquiry	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.18%

Appearance:Solid

Color:Yellow

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	Skp2 inhibitor 1 is a Skp2-Cks1 interaction inhibitor (IC50: 2.8μM) with antitumor activity and can be used to study cancer.
Targets & IC50	PC3 cells:4.8 μM, MGC-803 cells:7.0 μM
In vitro	Skp2 inhibitor 1 (2.8 μM, 72 h) was able to interfere with the interaction between Skp2 and Cks1, with IC50 values of 4.8 μM and 7.0 μM for PC-3 and MGC-803 cells, respectively. [1] At a concentration of 10 μM, after 48 h treatment, Skp2 inhibitor 1 was able to inhibit the proliferation and migration of PC-3 and MGC-803 cells, induced cell arrest in S phase, and promoted apoptosis. [1]
In vivo	Skp2 inhibitor 1, administered at doses of 10 mg/kg, 25 mg/kg, and 50 mg/kg via intragastric administration every two days over a 21-day period, significantly suppressed tumor growth in xenograft models of PC-3 and MGC-803 cells within NOD-SCID mice, showing no notable toxicity. A dose of 50 mg/kg (every 2 days) completely inhibited tumor growth [1]. The compound functions by inhibiting the Skp2 signaling pathway, thereby reducing tumor malignancy and increasing apoptotic cell proportions in tumor tissues [1]. The tumor growth inhibition ratios were 55.68%, 71.86%, and 90.42% for 10, 25, and 50 mg/kg respectively.

Chemical Properties

Molecular Weight	406.91
Formula	C₂₃H₂₃ClN₄O
Cas No.	2760612-63-1
Smiles	O=C(NC1CCN(C2=NC(C3=CC=CC=C3)=C(N=C2)C=4C=CC=CC4)CC1)CCl

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 132.5 mg/mL (325.62 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5.89 mg/mL (14.47 mM), Solution.

10% DMSO+90% Saline: < 5.89 mg/mL (14.47 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4575 mL	12.2877 mL	24.5755 mL	122.8773 mL
5 mM	0.4915 mL	2.4575 mL	4.9151 mL	24.5755 mL
10 mM	0.2458 mL	1.2288 mL	2.4575 mL	12.2877 mL
20 mM	0.1229 mL	0.6144 mL	1.2288 mL	6.1439 mL
50 mM	0.0492 mL	0.2458 mL	0.4915 mL	2.4575 mL
100 mM	0.0246 mL	0.1229 mL	0.2458 mL	1.2288 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Skp2

Related Tags: Skp2 inhibitor 1 chemical structure | Skp2 inhibitor 1 in vivo | Skp2 inhibitor 1 in vitro | Skp2 inhibitor 1 formula | Skp2 inhibitor 1 molecular weight