Anti-DR5 Polyclonal Antibody is a Rabbit antibody targeting DR5. Anti-DR5 Polyclonal Antibody can be used in WB,ICC/IF.

IgG

Human (predicted:Mouse,Rat)

1. Hela cell; 4% Paraformaldehyde-fixed; Triton X-100 at room temperature for 20 min; Blocking buffer (normal goat serum) at 37°C for 20 min; Antibody incubation with (DR5) polyclonal Antibody, Unconjugated (TMAB-05312) 1:100, 90 minutes at 37°C; followed by a conjugated Goat Anti-Rabbit IgG antibody at 37°C for 90 minutes, DAPI (blue) was used to stain the cell nuclei.
2. Sample: lovo Cell (Human) Lysate at 40 μg
Primary: Anti-DR5/CD262 at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 48 kD
Observed band size: 48 kD

WB: 1:500-2000; ICC/IF: 1:100-500

Polyclonal

KLH conjugated synthetic peptide: rat DR5

Rat

TNFRSF10B

Tumor necrosis factor receptor superfamily member 10B

Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.