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CP-465022 (maleate)

Catalog No. T21875 CAS 199656-46-7

CP-465022 Maleate is a potent, selective, noncompetitive AMPA receptor antagonist with anticonvulsant activity. It effectively counters the Kainate-induced response in rat cortical neurons, exhibiting an IC 50 of 25 nM. As such, CP-465022 Maleate presents a valuable instrument for studying the involvement of AMPA receptors in various physiological and pathophysiological processes [1] [2].

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CP-465022 (maleate), CAS 199656-46-7

Pack Size	Availability	Price/USD
1 mg	35 days	$ 78.00
5 mg	35 days	$ 233.00
10 mg	35 days	$ 383.00

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Description

In vitro

CP-465022 (0.0001 μM-10 μM) progressively inhibits kainate-induced responses based on its concentration, achieving a 50% inhibition concentration (IC50) of 25 nM, with near-total inhibition at 3.2 μM [1]. At a concentration of 1 μM for 10 minutes, CP-465022 marginally affects peak NMDA-induced currents but decreases the currents measured at 8 seconds by 26%. When increased to 10 μM, CP-465022 reduces peak NMDA-induced currents by 36% and significantly diminishes currents measured at the same time interval by 70% in primary cortical and cerebellar granule neuron cultures [1]. Similarly, a 10-minute exposure to 1 μM CP-465022 impedes peak NMDA currents by 19% and reduces subsequent currents at 8 seconds by 45% in rat cerebellar granule neuron cultures, aligning with effects observed in cortical neurons [1]. Furthermore, CP-465022 (100 nM-10 μM) demonstrates inhibitory actions on kainate-induced currents in rat hippocampal cells, with 100 nM CP-465022 suppressing the development of kainate currents over 200 seconds. Concentrations of 500 nM and 1 μM achieve almost complete inhibition (99.3%) within this timeframe [1].

Molecular Weight	579.02
Formula	C30H28ClFN4O5
CAS No.	199656-46-7

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CP-465022 (maleate) 199656-46-7 CP 465022 CP-465022 CP465022 (maleate) CP465022 CP 465022 (maleate) inhibitor inhibit

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