CP-465022 Maleate is a potent, selective, noncompetitive AMPA receptor antagonist with anticonvulsant activity, effectively countering the Kainate-induced response in rat cortical neurons with an IC50 of 25 nM, making it a valuable instrument for studying the involvement of AMPA receptors in various physiological and pathophysiological processes [1] [2].

CP-465022 (0.0001 μM-10 μM) inhibits kainate-induced responses in a concentration-dependent manner, with an IC50 of 25 nM and nearly complete inhibition at 3.2 μM [1]. At 1 μM for 10 minutes, it slightly affects peak NMDA-induced currents but reduces 8-second currents by 26%; at 10 μM, it decreases peak currents by 36% and 8-second currents by 70% in primary cortical and cerebellar granule neuron cultures [1]. In rat cerebellar granule neuron cultures, 1 μM for 10 minutes impairs peak NMDA currents by 19% and 8-second currents by 45%, similar to cortical neurons [1]. CP-465022 (100 nM-10 μM) also inhibits kainate-induced currents in rat hippocampal cells, with 100 nM suppressing current development over 200 seconds, and 500 nM and 1 μM causing nearly complete inhibition (99.3%) within this period [1].