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SIRT6 activator 12q

Name: SIRT6 activator 12q
Brand: TargetMol
SKU: T72484
Price: 49 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T72484 Copy Product Info

Purity: 98.53%

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SIRT6 activator 12q is a potent allosteric SIRT6 activator (EC50 = 5.3 μM). It enhances SIRT6-mediated histone deacetylation to regulate metabolism and longevity in aging and cancer research.

SIRT6 activator 12q

Copy Product Info

🥰Excellent

Catalog No. T72484

SIRT6 activator 12q is a potent allosteric SIRT6 activator (EC50 = 5.3 μM). It enhances SIRT6-mediated histone deacetylation to regulate metabolism and longevity in aging and cancer research.

Cas No. 2601734-99-8

Pack Size	Price	USA Stock	Global Stock
5 mg	$29	-	In Stock
10 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$49	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.53%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	SIRT6 activator 12q is a potent allosteric SIRT6 activator (EC50 = 5.3 μM). It enhances SIRT6-mediated histone deacetylation to regulate metabolism and longevity in aging and cancer research.
Targets&IC50	SIRT6:0.58 μM, SIRT1:171.20 uM
In vitro	SIRT6 activator 12q inhibits pancreatic cancer cell proliferation and reduces histone acetylation expression [1].
In vivo	Oral SIRT6 activator 12q (100-150 mg/kg) shows significant antitumor efficacy in PANC-1 xenografts [1].

Chemical Properties

Molecular Weight	454.52
Formula	C₃₁H₂₂N₂O₂
Cas No.	2601734-99-8
Smiles	O=C(NC(C=1C=CC=CC1)C=2C=CC=CC2)C3=CC(=NC=4C=CC=CC43)C=5OC=6C=CC=CC6C5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (44 mM), Sonication is recommmended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2001 mL	11.0006 mL	22.0012 mL	110.0062 mL
5 mM	0.4400 mL	2.2001 mL	4.4002 mL	22.0012 mL
10 mM	0.2200 mL	1.1001 mL	2.2001 mL	11.0006 mL
20 mM	0.1100 mL	0.5500 mL	1.1001 mL	5.5003 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc