PROTAC BRD4-binding moiety 1

Name: PROTAC BRD4-binding moiety 1
Brand: TargetMol
SKU: T18599
Rating: 4.5 (1 reviews)

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Catalog No. T18599Cas No. 2101200-10-4

PROTAC BRD4-binding moiety 1 is a BRD4 ligand that binds to the cereblon ligand via a linker, facilitating the formation of a PROTAC complex which efficiently degrades BRD4[1].

PROTAC BRD4-binding moiety 1

😃Good

Catalog No. T18599Cas No. 2101200-10-4

PROTAC BRD4-binding moiety 1 is a BRD4 ligand that binds to the cereblon ligand via a linker, facilitating the formation of a PROTAC complex which efficiently degrades BRD4[1].

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Product Introduction

Bioactivity

Description	PROTAC BRD4-binding moiety 1 is a BRD4 ligand that binds to the cereblon ligand via a linker, facilitating the formation of a PROTAC complex which efficiently degrades BRD4[1].
In vitro	PROTAC BRD4 Degrader-2 is an effective PROTAC BRD4 degrader, exhibiting an IC50 of 14.2 nM against BRD4 BD1 [1].

Chemical Properties

Molecular Weight	371.43
Formula	C₂₃H₂₁N₃O₂
Cas No.	2101200-10-4
Relative Density.	1.195 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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