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S55746

Name: S55746
Brand: TargetMol
SKU: T12824L
Price: 51 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12824LCas No. 1448584-12-0

Alias BLC201

S55746 (BLC201) is an effective and selective BCL-2 inhibitor (Ki: 1.3 nM and a Kd of 3.9 nM).

S55746

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Purity: 99.91%

Catalog No. T12824LAlias BLC201Cas No. 1448584-12-0

S55746 (BLC201) is an effective and selective BCL-2 inhibitor (Ki: 1.3 nM and a Kd of 3.9 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$51	In Stock	In Stock
2 mg	$74	In Stock	In Stock
5 mg	$110	In Stock	In Stock
10 mg	$200	In Stock	In Stock
25 mg	$363	In Stock	In Stock
50 mg	$578	In Stock	In Stock
100 mg	$833	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$133	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.91%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	S55746 (BLC201) is an effective and selective BCL-2 inhibitor (Ki: 1.3 nM and a Kd of 3.9 nM).
Targets&IC50	Bcl-2:3.9 nM (kd), Bcl-xL:520 nM (Ki), Bcl-2:1.3 nM (Ki), Bcl-xL:186 nM (Kd)
In vitro	S55746 selectively causes apoptosis through BCL-2 inhibition in a BAX/BAK-dependent manner. S55746 (0-1 μM) effectively and selectively induces cell death [1].
In vivo	S55746 is a potent and well-tolerated oral BCL-2 inhibitor, effective even at doses up to 300 mg/kg. At doses of 20-100 mg/kg (p.o.), S55746 inhibits xenograft growth in RS4 [1].
Synonyms	BLC201

Chemical Properties

Molecular Weight	710.82
Formula	C₄₃H₄₂N₄O₆
Cas No.	1448584-12-0
Smiles	Oc1ccc(cc1)N(C(=O)c1cc(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccccc1
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 44 mg/mL (61.9 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4068 mL	7.0341 mL	14.0683 mL	70.3413 mL
5 mM	0.2814 mL	1.4068 mL	2.8137 mL	14.0683 mL
10 mM	0.1407 mL	0.7034 mL	1.4068 mL	7.0341 mL
20 mM	0.0703 mL	0.3517 mL	0.7034 mL	3.5171 mL
50 mM	0.0281 mL	0.1407 mL	0.2814 mL	1.4068 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc