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Nizatidine

Name: Nizatidine
Brand: TargetMol
SKU: T1575
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1575Cas No. 76963-41-2

Alias Zanizal, Axid, Acinon

Nizatidine (Acinon) is a competitive and reversible histamine H2-receptor antagonist with antacid activity.

Nizatidine

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Purity: 99.43%

Catalog No. T1575Alias Zanizal, Axid, AcinonCas No. 76963-41-2

Nizatidine (Acinon) is a competitive and reversible histamine H2-receptor antagonist with antacid activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 g	$29	-	In Stock
5 g	$40	-	In Stock
10 g	$66	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.43%

Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	Nizatidine (Acinon) is a competitive and reversible histamine H2-receptor antagonist with antacid activity.
Targets&IC50	AChE:6.7 μM, H2 receptor:0.9 nM
In vitro	In rats, Nizatidine exhibits its maximum inhibitory effect on gastric acid secretion one hour after administration, with an EC50 value of 1.383 μMol/kg. Intravenous administration of Nizatidine (0.3-3 mg/kg) not only enhances gastrointestinal motility but also suppresses gastric acid secretion, achieving 50% of the maximal effect at a dose of 2.94 mg/kg and 90% at 19.6 mg/kg for rats.
In vivo	Nizatidine is a reversible, non-competitive inhibitor of acetylcholinesterase (IC50=6.7 μM, Ki=7.4 μM) and a selective antagonist of the histamine H2 receptor, effectively inhibiting gastric acid secretion (IC50=0.9 nM).
Synonyms	Zanizal, Axid, Acinon

Chemical Properties

Molecular Weight	331.46
Formula	C₁₂H₂₁N₅O₂S₂
Cas No.	76963-41-2
Smiles	CN\C(NCCSCc1csc(CN(C)C)n1)=C\[N+]([O-])=O
Relative Density.	1.249g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (181.02 mM), Sonication is recommended.

H2O: 26 mg/mL (78.44 mM), Sonication is recommended.

Ethanol: 15 mg/mL (45.25 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (9.96 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0170 mL	15.0848 mL	30.1696 mL	150.8478 mL
5 mM	0.6034 mL	3.0170 mL	6.0339 mL	30.1696 mL
10 mM	0.3017 mL	1.5085 mL	3.0170 mL	15.0848 mL
20 mM	0.1508 mL	0.7542 mL	1.5085 mL	7.5424 mL

H2O/DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0603 mL	0.3017 mL	0.6034 mL	3.0170 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0302 mL	0.1508 mL	0.3017 mL	1.5085 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc