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Nizatidine

Name: Nizatidine
Brand: TargetMol
SKU: T1575
Rating: 4.5 (1 reviews)

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Catalog No. T1575Cas No. 76963-41-2

Alias Zanizal, Axid, Acinon

Nizatidine (Acinon) is a competitive and reversible histamine H2-receptor antagonist with antacid activity.

Nizatidine

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Purity: 99.43%

Catalog No. T1575Alias Zanizal, Axid, AcinonCas No. 76963-41-2

Nizatidine (Acinon) is a competitive and reversible histamine H2-receptor antagonist with antacid activity.

Pack Size	Price	Availability	Quantity
1 g	$29	Backorder
1 mL x 10 mM (in DMSO)	$29	In Stock

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Purity:99.43%

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Product Introduction

Bioactivity

Description	Nizatidine (Acinon) is a competitive and reversible histamine H2-receptor antagonist with antacid activity.
Targets&IC50	H2 receptor:0.9 nM, AChE:6.7 μM
In vitro	In rats, Nizatidine exhibits its maximum inhibitory effect on gastric acid secretion one hour after administration, with an EC50 value of 1.383 μMol/kg. Intravenous administration of Nizatidine (0.3-3 mg/kg) not only enhances gastrointestinal motility but also suppresses gastric acid secretion, achieving 50% of the maximal effect at a dose of 2.94 mg/kg and 90% at 19.6 mg/kg for rats.
In vivo	Nizatidine is a reversible, non-competitive inhibitor of acetylcholinesterase (IC50=6.7 μM, Ki=7.4 μM) and a selective antagonist of the histamine H2 receptor, effectively inhibiting gastric acid secretion (IC50=0.9 nM).
Synonyms	Zanizal, Axid, Acinon

Chemical Properties

Molecular Weight	331.46
Formula	C₁₂H₂₁N₅O₂S₂
Cas No.	76963-41-2
Smiles	CN\C(NCCSCc1csc(CN(C)C)n1)=C\[N+]([O-])=O
Relative Density.	1.249g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (181.02 mM), Sonication is recommended.

H2O: 26 mg/mL (78.44 mM), Sonication is recommended.

Ethanol: 15 mg/mL (45.25 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (9.96 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0170 mL	15.0848 mL	30.1696 mL	150.8478 mL
5 mM	0.6034 mL	3.0170 mL	6.0339 mL	30.1696 mL
10 mM	0.3017 mL	1.5085 mL	3.0170 mL	15.0848 mL
20 mM	0.1508 mL	0.7542 mL	1.5085 mL	7.5424 mL

H2O/DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0603 mL	0.3017 mL	0.6034 mL	3.0170 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0302 mL	0.1508 mL	0.3017 mL	1.5085 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc