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AKT-IN-1

🥰Excellent
Catalog No. T4489Cas No. 1357158-81-6
Alias AZD-26, AZD26, AZD 26

AKT-IN-1 (AZD-26) is an allosteric AKT inhibitor (IC50: 1.04 μM).

AKT-IN-1

AKT-IN-1

🥰Excellent
Purity: 98.63%
Catalog No. T4489Alias AZD-26, AZD26, AZD 26Cas No. 1357158-81-6
AKT-IN-1 (AZD-26) is an allosteric AKT inhibitor (IC50: 1.04 μM).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$105In StockIn Stock
5 mg$247In StockIn Stock
10 mg$422In StockIn Stock
25 mg$687In StockIn Stock
50 mg$957In StockIn Stock
100 mg$1,290-In Stock
1 mL x 10 mM (in DMSO)$198In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.63%
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Product Introduction

Bioactivity
Description
AKT-IN-1 (AZD-26) is an allosteric AKT inhibitor (IC50: 1.04 μM).
Targets&IC50
Akt (allosteric):1.04 μM
In vitro
AZD-26 is able to potently inhibit phosphorylation of AKT in cells at both Thr308 (IC50: 0.422 μM) and Ser473 (IC50: 0.322 μM). AZD-26 inhibits the phosphorylation of ribosomal protein S6, a downstream effector of the PI3K-AKT pathway. AZD-26 potently inhibits the phosphorylation of PRAS40 [1].
In vivo
The effects of AZD-26 in vivo are characterized by measuring the pharmacodynamic activity of AZD-26 in a BT474c breast adenocarcinoma xenograft model. Following acute doses of 100 and 200 mg/kg, AZD-26 potently inhibits the phosphorylation of its downstream substrate GSK3β as well as the phosphorylation of AKT (Ser473), with a potency consistent with its pharmacokinetic profile. The in vivo activity of AZD-26 is further characterized by measuring the effects on the growth of tumour cell xenografts. Continuous (daily) oral dosing of AZD-26 (100 and 200 mg/kg) to nude mice bearing BT474c breast adenocarcinoma xenografts results in inhibition of tumour growth in a dose-dependent manner. When dosed at 200 mg/kg daily, AZD-26 causes significant tumour growth inhibition[1].
SynonymsAZD-26, AZD26, AZD 26
Chemical Properties
Molecular Weight343.42
FormulaC22H21N3O
Cas No.1357158-81-6
SmilesNC(=O)c1cnc(-c2ccc(cc2)C2(N)CCC2)c(c1)-c1ccccc1
Relative Density.1.210 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 11 mg/mL (32.03 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.82 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9119 mL14.5594 mL29.1189 mL145.5943 mL
5 mM0.5824 mL2.9119 mL5.8238 mL29.1189 mL
10 mM0.2912 mL1.4559 mL2.9119 mL14.5594 mL
20 mM0.1456 mL0.7280 mL1.4559 mL7.2797 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

Protein kinase BPKBInhibitorinhibitallosteric AktAKT-IN-1AKTIN1AKT IN 1Akt
Related Tags: buy AKT-IN-1 | purchase AKT-IN-1 | AKT-IN-1 cost | order AKT-IN-1 | AKT-IN-1 chemical structure | AKT-IN-1 in vivo | AKT-IN-1 in vitro | AKT-IN-1 formula | AKT-IN-1 molecular weight
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