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Mexiletine hydrochloride

Name: Mexiletine hydrochloride
Brand: TargetMol
SKU: T1046
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T1046Cas No. 5370-01-4

Alias Mexiletine HCl, KOE-1173 (hydrochloride), KO1173

Mexiletine hydrochloride (KOE-1173 hydrochloride) is a voltage-gated sodium channel blocker and a Class IB antiarrhythmic drug. Mexiletine hydrochloride exerts antiarrhythmic effects by inhibiting sodium current in myocardial cells, thereby reducing the rise rate of cardiac action potential (phase 0) and reducing the automaticity of Purkinje fibers.

Mexiletine hydrochloride

🥰Excellent

Purity: 99.88%

Catalog No. T1046Alias Mexiletine HCl, KOE-1173 (hydrochloride), KO1173Cas No. 5370-01-4

Pack Size	Price	Availability
50 mg	$35	In Stock
100 mg	$48	In Stock
200 mg	$59	In Stock
500 mg	$68	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Purity:99.88%

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COA LCMS HNMR HPLC

Product Introduction

Bioactivity

Description	Mexiletine hydrochloride (KOE-1173 hydrochloride) is a voltage-gated sodium channel blocker and a Class IB antiarrhythmic drug. Mexiletine hydrochloride exerts antiarrhythmic effects by inhibiting sodium current in myocardial cells, thereby reducing the rise rate of cardiac action potential (phase 0) and reducing the automaticity of Purkinje fibers.
In vitro	Mexiletine shortened the cardiac Purkinje fiber effective response period (ERP) less than the action potential duration (APD), resulting in higher ERP/APD ratios.Mexiletine had no significant effect on atrioventricular conduction velocity, resting membrane potential, sinus node autoregulation, systolic arterial pressure, left ventricular function, or QRS or QT intervals. Mexiletine inhibits the inward flow of sodium ions through inhibition of sodium channels (requiring pulse initiation and conduction), which in turn reduces the rate of action potential elevation.
In vivo	Mexiletine shortened the cardiac Purkinje fiber effective response period (ERP) less than the action potential duration (APD), resulting in higher ERP/APD ratios.Mexiletine had no significant effect on atrioventricular conduction velocity, resting membrane potential, sinus node autoregulation, systolic arterial pressure, left ventricular function, or QRS or QT intervals. Mexiletine inhibits the inward flow of sodium ions through inhibition of sodium channels (requiring pulse initiation and conduction), which in turn reduces the rate of action potential elevation.
Synonyms	Mexiletine HCl, KOE-1173 (hydrochloride), KO1173

Chemical Properties

Molecular Weight	215.72
Formula	C₁₁H₁₈ClNO
Cas No.	5370-01-4
Smiles	Cl.CC(N)COc1c(C)cccc1C
Relative Density.	1.12 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (231.78 mM), Sonication is recommended.

H2O: 21.6 mg/mL (100.13 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.27 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.6356 mL	23.1782 mL	46.3564 mL	231.7819 mL
5 mM	0.9271 mL	4.6356 mL	9.2713 mL	46.3564 mL
10 mM	0.4636 mL	2.3178 mL	4.6356 mL	23.1782 mL
20 mM	0.2318 mL	1.1589 mL	2.3178 mL	11.5891 mL
50 mM	0.0927 mL	0.4636 mL	0.9271 mL	4.6356 mL
100 mM	0.0464 mL	0.2318 mL	0.4636 mL	2.3178 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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