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Pimethixene maleate

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Catalog No. T12489LCas No. 13187-06-9
Alias Pimetixene maleate

Pimethixene maleate (Pimetixene maleate) is a potent 5-HT2B receptor antagonist with sedative and antitussive activity.Pimethixene maleate inhibits 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2, and can be used in studies of dry and irritant cough in children. irritant cough in children.

Pimethixene maleate
Other Forms of Pimethixene maleate:
PimethixeneT12489314-03-4
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Pimethixene maleate

🥰Excellent
Purity: 99.55%
Catalog No. T12489LAlias Pimetixene maleateCas No. 13187-06-9
Pimethixene maleate (Pimetixene maleate) is a potent 5-HT2B receptor antagonist with sedative and antitussive activity.Pimethixene maleate inhibits 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2, and can be used in studies of dry and irritant cough in children. irritant cough in children.
Pack SizePriceAvailabilityQuantity
5 mg$30In Stock
10 mg$48In Stock
25 mg$77In Stock
50 mgPreferentialIn Stock
1 mL x 10 mM (in DMSO)$53In Stock
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Purity:99.55%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
Pimethixene maleate (Pimetixene maleate) is a potent 5-HT2B receptor antagonist with sedative and antitussive activity.Pimethixene maleate inhibits 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2, and can be used in studies of dry and irritant cough in children. irritant cough in children.
Targets&IC50
M2 mAChR:9.38 (pKi), M1 mAChR:8.61 (pKi), 5-HT2B receptor:10.44 (pKi), 5-HT2C receptor:8.42 (pKi), DD4.4 receptor:7.54 (pKi), 5-HT2A receptor:10.22 (pKi), D2 receptor:8.19 (pKi), H1 receptor:10.14 (pKi), 5-HT1A receptor:7.63 (pKi)
SynonymsPimetixene maleate
Chemical Properties
Molecular Weight409.5
FormulaC23H23NO4S
Cas No.13187-06-9
SmilesOC(=O)\C=C/C(O)=O.CN1CCC(CC1)=C1c2ccccc2Sc2ccccc12
Relative Density.1.192g/cm3
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (195.36 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4420 mL12.2100 mL24.4200 mL122.1001 mL
5 mM0.4884 mL2.4420 mL4.8840 mL24.4200 mL
10 mM0.2442 mL1.2210 mL2.4420 mL12.2100 mL
20 mM0.1221 mL0.6105 mL1.2210 mL6.1050 mL
50 mM0.0488 mL0.2442 mL0.4884 mL2.4420 mL
100 mM0.0244 mL0.1221 mL0.2442 mL1.2210 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

Pimethixene maleateM2 receptorM2 mAChRM1 receptorM1 mAChRHistamineReceptorHistamine ReceptorH1 receptorDopamineReceptorDopamine ReceptorDD4.4 receptorD2 receptorD25HTReceptor5-HT2C Receptor5-HT2B Receptor5-HT2A Receptor5-HT1A Receptor5HT Receptor5-HT
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