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GS-9256

Catalog No. T71653 CAS 1001094-46-7

GS-9256 is a selective inhibitor of the HCV NS3 protease, exhibiting favorable pharmacokinetic properties and antiviral activity [1].

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GS-9256, CAS 1001094-46-7

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	GS-9256 is a selective inhibitor of the HCV NS3 protease, exhibiting favorable pharmacokinetic properties and antiviral activity [1].
In vitro	GS-9256 demonstrates potent antiviral activity with a mean EC50 of 20 nM across a concentration range of 0.002-0.183 μM in GT1b huh-luc cells harboring a luciferase-encoding replicon [1]. Furthermore, at 3 μM, GS-9256 maintains efficacy against all tested resistant mutations in NS5B and NS5A inhibitors, showcasing its metabolic stability in microsomes and hepatocytes from rodents, dogs, and humans [1].
In vivo	GS-9256 exhibits high bioavailability in mice (approximately 100%) when administered intravenously at 1 mg/kg with a 30-minute exposure, while showing moderate bioavailability in rats (14%), dogs (21%), and monkeys (14%). The compound's elimination half-life spans approximately 2 hours in mice, 0.6 hours in rats, 5 hours in dogs, and 4 hours in monkeys. Regarding the pharmacokinetic parameters at indicated doses for each species (IV: 2 mg/kg in mice, 1 mg/kg in rats, dogs, and monkeys; Oral: 50 mg/kg in mice, 5 mg/kg in rats and monkeys, and 4 mg/kg in dogs), they are as follows: for the CD-1 mouse, Sprague-Dawley rat, Beagle dog, and Cynomolgus monkey, the clearance (CL) is 2.0, 1.26, 0.04, and 0.33 L/h/kg respectively, while the volume of distribution at steady state (Vss) is 2.3, 0.16, 0.09, and 0.27 L/kg respectively [1].

Molecular Weight	957.46
Formula	C46H56ClF2N6O8PS
CAS No.	1001094-46-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GS-9256 1001094-46-7 Microbiology/Virology Proteases/Proteasome HCV Protease GS 9256 GS9256 KX-1141 KX 1141. inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.