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VU0453595

Name: VU0453595
Brand: TargetMol
SKU: T29137
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T29137Cas No. 1432436-13-9

Alias VU-0453595, VU 0453595

VU0453595 is a M1 positive allosteric modulator (PAM).

VU0453595

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Purity: 99.91%

Catalog No. T29137Alias VU-0453595, VU 0453595Cas No. 1432436-13-9

VU0453595 is a M1 positive allosteric modulator (PAM).

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$38	In Stock	In Stock
5 mg	$58	In Stock	In Stock
10 mg	$98	In Stock	In Stock
25 mg	$191	In Stock	In Stock
50 mg	$296	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$58	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.91%

Appearance:Solid

Color:White

Resource Download

COA LCMS

Product Introduction

VU0453595 AI Summary

VU0453595 exhibits positive allosteric modulation at both rat and human muscarinic acetylcholine receptor M1, enhancing acetylcholine-induced calcium mobilization with EC50 values of 3200.0 nM and 1900.0 nM for rat and human receptors, respectively. Additionally, it affects beta-arrestin recruitment at the human receptor with an EC50 value of 2600.0 nM. The compound shows selectivity towards the rat receptor with a selectivity ratio of 3.0. In Sprague-Dawley rats, the brain-to-plasma partition coefficient is Kp = 0.3 following intravenous administration..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	VU0453595 is a M1 positive allosteric modulator (PAM).
Synonyms	VU-0453595, VU 0453595

Chemical Properties

Molecular Weight	322.34
Formula	C₁₈H₁₅FN₄O
Cas No.	1432436-13-9
Smiles	Cn1cc(cn1)-c1ccc(CN2Cc3ncccc3C2=O)c(F)c1
Relative Density.	1.35 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (310.23 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (12.41 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1023 mL	15.5116 mL	31.0231 mL	155.1157 mL
5 mM	0.6205 mL	3.1023 mL	6.2046 mL	31.0231 mL
10 mM	0.3102 mL	1.5512 mL	3.1023 mL	15.5116 mL
20 mM	0.1551 mL	0.7756 mL	1.5512 mL	7.7558 mL
50 mM	0.0620 mL	0.3102 mL	0.6205 mL	3.1023 mL
100 mM	0.0310 mL	0.1551 mL	0.3102 mL	1.5512 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc