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VU0453595

Name: VU0453595
Brand: TargetMol
SKU: T29137
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T29137Cas No. 1432436-13-9

Alias VU-0453595, VU 0453595

VU0453595 is a M1 positive allosteric modulator (PAM).

VU0453595

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Purity: 99.91%

Catalog No. T29137Alias VU-0453595, VU 0453595Cas No. 1432436-13-9

VU0453595 is a M1 positive allosteric modulator (PAM).

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$38	In Stock	In Stock
5 mg	$58	In Stock	In Stock
10 mg	$98	In Stock	In Stock
25 mg	$191	In Stock	In Stock
50 mg	$296	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$58	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.91%

Resource Download

COA LCMS

Product Introduction

Bioactivity

Description	VU0453595 is a M1 positive allosteric modulator (PAM).
Synonyms	VU-0453595, VU 0453595

Chemical Properties

Molecular Weight	322.34
Formula	C₁₈H₁₅FN₄O
Cas No.	1432436-13-9
Smiles	Cn1cc(cn1)-c1ccc(CN2Cc3ncccc3C2=O)c(F)c1
Relative Density.	1.35 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (310.23 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (12.41 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1023 mL	15.5116 mL	31.0231 mL	155.1157 mL
5 mM	0.6205 mL	3.1023 mL	6.2046 mL	31.0231 mL
10 mM	0.3102 mL	1.5512 mL	3.1023 mL	15.5116 mL
20 mM	0.1551 mL	0.7756 mL	1.5512 mL	7.7558 mL
50 mM	0.0620 mL	0.3102 mL	0.6205 mL	3.1023 mL
100 mM	0.0310 mL	0.1551 mL	0.3102 mL	1.5512 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc