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Anti-RALBP1 Antibody (8I172)

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Catalog No. TMAB-12062

Anti-RALBP1 Antibody (8I172) is a Rabbit antibody targeting RALBP1. Anti-RALBP1 Antibody (8I172) can be used in WB,IHC-P,IHC-Fr,FCM,IF.

Anti-RALBP1 Antibody (8I172)

Anti-RALBP1 Antibody (8I172)

😃Good
Catalog No. TMAB-12062
Anti-RALBP1 Antibody (8I172) is a Rabbit antibody targeting RALBP1. Anti-RALBP1 Antibody (8I172) can be used in WB,IHC-P,IHC-Fr,FCM,IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 μL$1487-10 days7-10 days
50 μL$2617-10 days7-10 days
100 μL$4737-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-RALBP1 Antibody (8I172) is a Rabbit antibody targeting RALBP1. Anti-RALBP1 Antibody (8I172) can be used in WB,IHC-P,IHC-Fr,FCM,IF.
Ig Type
IgG
Clone
8I172
Reactivity
Human,Mouse,Rat
Application
WB
IHC-P
IHC-Fr
FCM
IF
Recommended Dose
WB: 1:500-2000; IHC-P: 1:100-200; IHC-Fr: 1:100-200; FCM: 1:50-100; IF: 1:100-200
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationMembrane, Peripheral membrane protein.
Tissue SpecificityExpressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes.
ConstructionRecombinant Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
Research BackgroundMultifunctional protein that functions as a downstream effector of RALA and RALB.As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity.As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis.
Antigen Details
Immunogen
A synthesized peptide: human RalBP1
Antigen Species
Human
Gene Name
RALBP1
Gene ID
10928
Protein Name
RalA-binding protein 1
Uniprot ID
Q15311
Function
Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.
Chemical Properties
Molecular WeightTheoretical: 76 kDa. Actual: 95 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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