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Dapivirine

Name: Dapivirine
Brand: TargetMol
SKU: T1815
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1815Cas No. 244767-67-7

Alias TMC120, R147681

Dapivirine (R147681) is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor.

Dapivirine

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Purity: 99.77%

Catalog No. T1815Alias TMC120, R147681Cas No. 244767-67-7

Dapivirine (R147681) is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor.

Pack Size	Price	Availability
10 mg	$30	In Stock
25 mg	$60	In Stock
50 mg	$91	In Stock
100 mg	$138	In Stock
200 mg	$198	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Purity:99.77%

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Product Introduction

Bioactivity

Description	Dapivirine (R147681) is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor.
Targets&IC50	HIV RT:24 nM
In vivo	Dapivirine-containing gel at vaginal level inhibits cell-associated HIV infection in mice. [3] More placebo (7 of 12) than Dapivirine (3 of 24) gel users has positive vaginal swab results, with white blood cells being the most common finding. Dapivirine (0.05%) results in Cmax of 715 pg/mL, AUC of 15 ng×h/mL and T1/2 of 89.87 hours in plasma after 14 days post-dose. Mean Dapivirine (0.05%) concentrations in vaginal fluids collected at the introitus, mid vagina, and cervix are in the range of 62-265 μg/g on day 1. [4]
Synonyms	TMC120, R147681

Chemical Properties

Molecular Weight	329.4
Formula	C₂₀H₁₉N₅
Cas No.	244767-67-7
Smiles	N(C1=C(C)C=C(C)C=C1C)C2=NC(NC3=CC=C(C#N)C=C3)=NC=C2
Relative Density.	1.23g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 32 mg/mL (97.15 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0358 mL	15.1791 mL	30.3582 mL	151.7911 mL
5 mM	0.6072 mL	3.0358 mL	6.0716 mL	30.3582 mL
10 mM	0.3036 mL	1.5179 mL	3.0358 mL	15.1791 mL
20 mM	0.1518 mL	0.7590 mL	1.5179 mL	7.5896 mL
50 mM	0.0607 mL	0.3036 mL	0.6072 mL	3.0358 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc