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CLZ-8

Name: CLZ-8
Brand: TargetMol
SKU: T16030
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16030Cas No. 678158-55-9

Alias Mcl1-IN-8, CLZ8, CLZ 8

CLZ-8 (Mcl1-IN-8) is an orally active inhibitor of Mcl-1-PUMA (p53 up-regulated mediator of apoptosis) with radioprotective properties.CLZ-8 ameliorates radiation-induced HUVEC cell damage and reduces apoptosis counts, and inhibits radiation-induced overexpression of PUMA.

CLZ-8

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Purity: 99.85%

Catalog No. T16030Alias Mcl1-IN-8, CLZ8, CLZ 8Cas No. 678158-55-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$43	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.85%

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COA LCMS

Product Introduction

Bioactivity

Description	CLZ-8 (Mcl1-IN-8) is an orally active inhibitor of Mcl-1-PUMA (p53 up-regulated mediator of apoptosis) with radioprotective properties.CLZ-8 ameliorates radiation-induced HUVEC cell damage and reduces apoptosis counts, and inhibits radiation-induced overexpression of PUMA.
Targets&IC50	MCL1:0.3 μM (Ki)
In vitro	In DLD-1 cells or HUVEC cells, CLZ-8 (0-160 μM; 48 hours for DLD-1 or 24 hours for HUVECs) significantly inhibits PUMA-dependent apoptosis with an IC50 of 38.93 ± 0.91 μM and attenuates radiation-induced apoptosis[1].
In vivo	In 6-8 week-old male BALB/c mice, CLZ-8 (100, 200, and 400 mg/kg; intragastric administration, once, 30 minutes prior to irradiation) increases the survival rate of irradiated mice[2].
Synonyms	Mcl1-IN-8, CLZ8, CLZ 8

Chemical Properties

Molecular Weight	393.5
Formula	C₂₂H₂₃N₃O₂S
Cas No.	678158-55-9
Smiles	OCCN1CCN(CC1)C1=NC(=O)\C(S1)=C\c1ccc(cc1)-c1ccccc1
Relative Density.	1.27 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (101.65 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 1 mg/mL (2.54 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5413 mL	12.7065 mL	25.4130 mL	127.0648 mL
5 mM	0.5083 mL	2.5413 mL	5.0826 mL	25.4130 mL
10 mM	0.2541 mL	1.2706 mL	2.5413 mL	12.7065 mL
20 mM	0.1271 mL	0.6353 mL	1.2706 mL	6.3532 mL
50 mM	0.0508 mL	0.2541 mL	0.5083 mL	2.5413 mL
100 mM	0.0254 mL	0.1271 mL	0.2541 mL	1.2706 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc